p11 mediates the BDNF-protective effects in dendritic outgrowth and spine formation in B27-deprived primary hippocampal cells

Journal of Affective Disorders
Sung Woo ParkYoung Hoon Kim

Abstract

p11 (S100A10) is a key regulator of depression-like behaviors and antidepressant drug response in rodent models. Recent studies suggest that p11 mediates the behavioral antidepressant action of brain-derived neurotrophic factor (BDNF) in rodents. BDNF improves neural plasticity, which is linked to the cellular actions of antidepressant drugs. In the present study, we investigated whether p11 regulated BDNF action on neural plasticity in vitro. We generated primary hippocampal cultures. p11 expression, total dendritic length, and spine density were investigated under toxic conditions induced by B27 deprivation, which causes hippocampal cell death. B27 deprivation significantly decreased p11 expression. Treatment with BDNF significantly prevented the B27 deprivation-induced decrease in p11 levels in a concentration-dependent manner, whereas these concentrations had no effect on control cultures. B27 deprivation significantly reduced the total length of hippocampal dendrites and spine density. BDNF increased the total dendritic length and spine density in conditions with or without B27. Furthermore, p11 knockdown through small interfering RNA (siRNA) transfection blocked these effects. The overexpression of p11 in B27-deprived cel...Continue Reading

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Citations

Sep 17, 2016·Journal of Neuroinflammation·Pejman Rahimian, Johnny J He
Jan 23, 2018·Translational Psychiatry·Alexandra NeyaziWolfgang Löscher
May 23, 2020·Molecular Psychiatry·Revathy U ChottekalapandaPaul Greengard
Oct 25, 2020·International Journal of Molecular Sciences·Luca Colucci-D'AmatoFloriana Volpicelli

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