p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis

Gene
Maria del Pilar Camacho LealSara Cabodi

Abstract

BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell-extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions.

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Citations

Feb 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Joerg KumbrinkKathrin H Kirsch
Nov 6, 2018·Cell Communication and Signaling : CCS·Maria Del Pilar Camacho LealSara Cabodi
Sep 26, 2020·Scientific Reports·Laura WisniewskiPaul Frankel
Dec 22, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Tsuyoshi ShimohiraAkira Aoki
Dec 29, 2020·The International Journal of Biochemistry & Cell Biology·Lenka KoudelkováDaniel Rosel
Nov 5, 2020·British Journal of Cancer·Alvin Kunyao GuoKoji Itahana
Aug 3, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Tsuyoshi ShimohiraAkira Aoki
Aug 18, 2021·Stroke; a Journal of Cerebral Circulation·Mark K Bakker, Ynte M Ruigrok
Aug 16, 2021·Pharmacology & Therapeutics·Eijiro JimiIchiro Nakamura

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