P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Nadja NikolicJelena Milasin

Abstract

To investigate the prevalence of p16INK4 a, p14ARF, tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P<.001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P< .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modes...Continue Reading

References

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ToyotaJ P Issa
Dec 19, 2001·The Journal of Pathology·Manel Esteller, James G Herman
Aug 22, 2002·Virchows Archiv : an International Journal of Pathology·Anette WeberAndrea Tannapfel
Oct 11, 2002·The Journal of Pathology·Anette WeberAndrea Tannapfel
Mar 1, 2003·British Journal of Cancer·B KlumpM Gregor
Jul 19, 2005·Acta Neuropathologica·Vishwa Jeet AmatyaHiroko Ohgaki
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michelle D WilliamsAdel K El-Naggar
Jan 16, 2007·International Journal of Oral and Maxillofacial Surgery·X-L GuoB-L Ma
Apr 1, 2008·Journal of Alzheimer's Disease : JAD·Patrícia Natália Oliveira SilvaMarília de Arruda Cardoso Smith
Jun 18, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Satoru MiyabeHiroshi Inagaki
Sep 8, 2009·The Journal of Nutritional Biochemistry·Kyong-chol KimSang-Woon Choi
Jan 19, 2011·Virchows Archiv : an International Journal of Pathology·Jacinthe ChenevertSimion I Chiosea
Aug 5, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Ricardo Saldaña-Meyer, Félix Recillas-Targa
Feb 23, 2012·Journal of Nutrigenetics and Nutrigenomics·Thomas Prates OngSharon Ann Ross
Mar 3, 2012·Gene·Michael DanielTrygve O Tollefsbol
Jul 10, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Felipe Paiva FonsecaPablo Agustin Vargas
Aug 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Xia GongYazhu Chen
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kowan Ja JeeIlmo Leivo
Feb 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jong-Lyel RohWayne M Koch
Apr 23, 2013·Biochimica Et Biophysica Acta·Zakir Khan, Prakash S Bisen
Jan 7, 2014·Mechanisms of Ageing and Development·Maria Giulia BacaliniPaolo Garagnani
Feb 5, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marietta TanPatrick K Ha
Mar 21, 2015·Archives of Oral Biology·Sabrina Rocha Luna De OliveiraNaila Francis Paulo De Oliveira
Apr 14, 2015·Epigenetics : Official Journal of the DNA Methylation Society·J M DevaneyB Kwabi-Addo
May 10, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·M H MullinP M Speight

❮ Previous
Next ❯

Citations

Dec 13, 2019·Oral Diseases·Erison S Dos SantosAdriana F Paes Leme
Aug 3, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Douglas Magno GuimarãesFabio Daumas Nunes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.