PMID: 18418067Apr 18, 2008Paper

p14ARF is capable of promoting HIV-1 tat degradation

Cell Cycle
Barbara GarganoLuigi Lania

Abstract

The p14(ARF) tumor suppressor functions as 'oncogenic checkpoint' that prevents unrestricted cellular proliferation in response to oncogenic signaling. Albeit, the major pathway through which ARF operates is the ARF-Mdm2-p53 axis, ARF directly binds to and inactivates transcription function of a number of DNA-bound activators. In the present study we show that p14(ARF) inhibits transcription activation of HIV-1 LTR promoter activity by Tat protein. Tat protein is a RNA-bound transcriptional activator whose function is strictly required for HIV-1 replication. We determined that p14(ARF) inhibits Tat transactivation of HIV-1 LTR by promoting Tat degradation via an ubiquitin-independent pathway.

Citations

Sep 4, 2009·Journal of Virology·Haran SivakumaranDavid Harrich
Sep 23, 2008·FEBS Letters·Alessandra PolliceGirolama La Mantia
Dec 8, 2010·The Biochemical Journal·Jia ShenChuangui Wang
Jun 15, 2011·Biochimica Et Biophysica Acta·Jiwon HwangRobert F Kalejta
Nov 22, 2008·Biochimica Et Biophysica Acta·Giovanni PassiatoreFrancesca Peruzzi
Dec 14, 2018·Frontiers in Microbiology·Sneh LataAkhil C Banerjea
Jan 31, 2021·Scientific Reports·Amina Ait-AmmarOlivier Rohr

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