p14ARF, p15INK4b and p16INK4a methylation status in chronic myelogenous leukemia

Leukemia & Lymphoma
Sophie KusyJoëlle Roche

Abstract

The INK4 family of proteins p15INK4b, p14ARF and p16INK4a function as cell cycle inhibitors where they are involved in the inhibition of G1 phase progression. Methylation of the p15INK4b promoter never seems to occur in solid tumors but is a major gene silencing mechanism in hematological malignancies. p14ARF and p16INK4a promoter methylation often occurs in solid tumors but also in leukemias and lymphomas. In chronic myelogenous leukemia (CML), only a few reports have been published regarding INK4 methylation and the results of the literature are discordant. Thus clearly, more works on large series have to be performed independently.

References

May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Oct 1, 1996·Leukemia & Lymphoma·M Heyman, S Einhorn
Apr 29, 1999·The New England Journal of Medicine·C L Sawyers
Nov 11, 1999·Leukemia·T TaniguchiT Motokura
Dec 28, 1999·Leukemia & Lymphoma·B Quesnel, P Fenaux
Mar 24, 2000·Trends in Genetics : TIG·S B Baylin, J G Herman
Apr 18, 2002·Applied Optics·J M Howard
Feb 8, 2003·Current Opinion in Genetics & Development·Scott W Lowe, Charles J Sherr
Mar 7, 2003·Molecular Cell·Masataka SugimotoCharles J Sherr
Mar 20, 2003·Experimental Hematology·Juan-Carlos Hernández-BoludaEmilio Montserrat
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E NagyF D Tóth
Nov 19, 2003·Current Opinion in Oncology·Jean-Pierre Issa

❮ Previous
Next ❯

Citations

Jan 25, 2013·The Journal of Veterinary Medical Science·Aki Fujiwara-IgarashiHajime Tsujimoto
Nov 13, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D Y XiaY M Liang
May 17, 2006·Technology in Cancer Research & Treatment·Krishan BansalJames T Rutka
Dec 24, 2005·Genes, Chromosomes & Cancer·Robert J Weeks, Ian M Morison
Oct 3, 2007·Cancer Research·Sergio Ruiz-LlorenteUNKNOWN Medullary Thyroid Carcinoma Clinical Group
Jun 14, 2019·Molecular Cancer Research : MCR·Yen-Ting LiuStephen X Skapek

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.