Abstract
Recent studies have revealed that cervical cancers associated with high-risk human papillomavirus (HPV) showed overexpression of the p16 protein, a cyclin-dependent kinase inhibitor. The expression of this cell cycle regulator in lesions of the anogenital region in association with HPV physical status (episomal or integrated) has not been studied at the present time. In this report, immunohistochemical analysis of p16 and HPV detection by in situ hybridization were performed on 110 formalin-fixed and paraffin-embedded samples of anogenital lesions. The results showed strong diffuse p16 staining in all integrated high-risk HPV-positive lesions, whereas most episomal HPV-positive lesions or HPV-negative lesions showed no p16 immunostaining. However, there were a few HPV-negative lesions or lesions with episomal HPV harboring p16 overexpression. On the other hand, some lesions were p16 negative while showing the presence of high-risk HPV in its episomal form. In conclusion, screening for p16 overexpression in cutaneomucous lesions of the anogenital region allowed good discrimination between HPV-integrated lesions and lesions harboring episomal HPV or no HPV. But p16 overexpression was not always predictive of the presence of high-...Continue Reading
References
Dec 1, 1991·Journal of Clinical Pathology·K CooperJ O McGee
Feb 17, 1989·Science·N DysonE Harlow
Nov 1, 1995·The Journal of Infectious Diseases·E R UngerW C Reeves
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S N KhleifP M Howley
Jan 1, 1997·Journal of Immunotherapy·P A FetschY M Hijazi
Jun 10, 1998·The Journal of Investigative Dermatology·R Keller-MelchiorM Piepkorn
Dec 10, 1998·The American Journal of Pathology·T SanoT Nakajima
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Aug 14, 2001·Virchows Archiv : an International Journal of Pathology·K Milde-LangoschT Löning
Dec 26, 2001·Oncogene·H zur Hausen
Oct 5, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Brigitte SamamaNelly Boehm
Nov 21, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M von Knebel Doeberitz
Nov 26, 2002·Virus Research·Karl Münger, Peter M Howley
Sep 2, 2003·The Journal of Pathology·Emmanuelle FerreuxPeter J F Snijders
Sep 4, 2003·Journal of the National Cancer Institute·Nicolas F SchlechtEduardo L Franco
Dec 17, 2003·Gynecologic Oncology·Hiroshi TsudaKumio Yamamoto
Jan 14, 2004·International Journal of Oncology·Hong Zhang, Inger Rosdahl
Mar 11, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ingo NindlEggert Stockfleth
Mar 26, 2004·American Journal of Obstetrics and Gynecology·John O SchorgeRaheela Ashfaq
May 20, 2004·The British Journal of Dermatology·O SimonettiA Offidani
Dec 1, 2004·International Journal of Dermatology·A N EliasV S Nanda
Dec 25, 2004·Human Pathology·Sabine RiethdorfLutz Riethdorf
Citations
Dec 1, 2007·Head and Neck Pathology·Samir K El-Mofty
Apr 14, 2016·Human Pathology·Aparna Mahajan
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Brigiet M HoevenaarsJohan Bulten
May 28, 2013·Journal of the American Academy of Dermatology·Viktoryia KazlouskayaDirk Elston
Aug 14, 2015·PloS One·M Cristina AntalNelly Boehm
Apr 5, 2008·Gynecologic Oncology·Brigitte SamamaNelly Boehm
Jan 18, 2014·International Journal of STD & AIDS·Rahul AroraVizodilhou A Yhome
Apr 7, 2007·The American Journal of Surgical Pathology·Sarah M BeanDavid C Chhieng
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Joan E BernardNoel Weidner
Jun 25, 2009·Journal of Lower Genital Tract Disease·Sarah M BeanDavid C Chhieng
Oct 24, 2009·Breast Cancer Research and Treatment·Gitana Maria AcetoErnesto Jorge Podestà
Feb 9, 2010·The American Journal of Surgical Pathology·Alcides ChauxAntonio L Cubilla
Nov 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B SamamaN Boehm
Oct 1, 2019·Journal of Cutaneous Pathology·Jean C B FerreiraElismauro F Mendonça
Mar 9, 2019·Frontiers in Oncology·Maria Raffaella AmbrosioPiero Tosi
Jul 8, 2021·The American Journal of Surgical Pathology·Yuxin LiuMichael M Gaisa