p16 expression in relation to human papillomavirus in anogenital lesions

Human Pathology
Brigitte SamamaNelly Boehm

Abstract

Recent studies have revealed that cervical cancers associated with high-risk human papillomavirus (HPV) showed overexpression of the p16 protein, a cyclin-dependent kinase inhibitor. The expression of this cell cycle regulator in lesions of the anogenital region in association with HPV physical status (episomal or integrated) has not been studied at the present time. In this report, immunohistochemical analysis of p16 and HPV detection by in situ hybridization were performed on 110 formalin-fixed and paraffin-embedded samples of anogenital lesions. The results showed strong diffuse p16 staining in all integrated high-risk HPV-positive lesions, whereas most episomal HPV-positive lesions or HPV-negative lesions showed no p16 immunostaining. However, there were a few HPV-negative lesions or lesions with episomal HPV harboring p16 overexpression. On the other hand, some lesions were p16 negative while showing the presence of high-risk HPV in its episomal form. In conclusion, screening for p16 overexpression in cutaneomucous lesions of the anogenital region allowed good discrimination between HPV-integrated lesions and lesions harboring episomal HPV or no HPV. But p16 overexpression was not always predictive of the presence of high-...Continue Reading

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Citations

Dec 1, 2007·Head and Neck Pathology·Samir K El-Mofty
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Brigiet M HoevenaarsJohan Bulten
Apr 5, 2008·Gynecologic Oncology·Brigitte SamamaNelly Boehm
Apr 7, 2007·The American Journal of Surgical Pathology·Sarah M BeanDavid C Chhieng
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Joan E BernardNoel Weidner
Jun 25, 2009·Journal of Lower Genital Tract Disease·Sarah M BeanDavid C Chhieng
Oct 24, 2009·Breast Cancer Research and Treatment·Gitana Maria AcetoErnesto Jorge Podestà
Nov 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B SamamaN Boehm
Oct 1, 2019·Journal of Cutaneous Pathology·Jean C B FerreiraElismauro F Mendonça

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