p16, HPV, and Cetuximab: What Is the Evidence?

The Oncologist
James A BonnerJ B Vermorken

Abstract

Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. It has recently been appreciated that human papillomavirus (HPV) status (or p16 status, which is a frequently used surrogate for HPV status) is prognostic for oropharyngeal SCCHN. Here, we review and contextualize existing p16 and HPV data, focusing on the cetuximab registration trials in previously untreated, locoregionally advanced, nonmetastatic SCCHN (LA SCCHN) and in recurrent and/or metastatic SCCHN (R/M SCCHN): the IMCL-9815 and EXTREME clinical trials, respectively. Taken together, the available data suggest that, while p16 and HPV are prognostic biomarkers in patients with LA SCCHN and R/M SCCHN, it could not be shown that they are predictive for the outcomes of the described cetuximab-containing trial regimens. Consequently, although HPV status provides prognostic information, it is not shown to predict therapy response, and so is not helpful for assigning first-line therapy in patients with SCCHN. In addition, we discuss assays currently used to assess p16 and HPV status, as well as the differentiation between these two biomarkers. Ultimately, we believe HPV E6/E7 polymerase chain reaction-based mRNA testing may represent ...Continue Reading

References

May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J AdelsteinArlene A Forastiere
Feb 25, 2003·The American Journal of Pathology·Jens P KlussmannPawel G Fuchs
Jan 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul M WeinbergerAmanda Psyrri
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Sep 5, 2006·Lancet·Jean BourhisUNKNOWN Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Desmond CurranJames A Bonner
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-Pierre PignonUNKNOWN MACH-NC Collaborative Group
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Na ZhangReidar Grénman
Mar 26, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R MesíaJ B Vermorken
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V GrégoireUNKNOWN EHNS-ESMO-ESTRO Guidelines Working Group
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert L FerrisSoldano Ferrone
Sep 30, 2010·International Journal of Cancer. Journal International Du Cancer·Maria BlombergSusanne Krüger Kjaer
Feb 5, 2011·Journal of the National Cancer Institute·Jill KoshiolNeil E Caporaso
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Nov 26, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R GranataL Licitra
Jun 30, 2012·The American Journal of Surgical Pathology·Richard C JordanMaura L Gillison
Dec 22, 2012·CA: a Cancer Journal for Clinicians·Dan P ZandbergKevin J Cullen
Nov 20, 2013·International Journal of Cancer. Journal International Du Cancer·Michelle M RietbergenRuud H Brakenhoff
Feb 27, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A SpreaficoL L Siu
Oct 1, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine H ChungQuynh-Thu Le
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael ParfenovUNKNOWN Cancer Genome Atlas Network
Nov 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tanguy Y Seiwert
Dec 11, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michaela K KeckTanguy Y Seiwert
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Mar 18, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria RusanPeter S Hammerman
Mar 31, 2015·Virchows Archiv : an International Journal of Pathology·Franziska HauckGerald Niedobitek
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinQuynh-Thu Le
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maura L GillisonCarole Fakhry
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Assuntina G Sacco, Ezra E Cohen
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aarti Bhatia, Barbara Burtness
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Neil HayesTanguy Y Seiwert

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT01302834
NCT01874171
NCT01855451
NCT01084083
NCT02254278
NCT01898494

Software Mentioned

CONCERT
EXTREME
SPECTRUM

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.