p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions

Fertility and Sterility
Anastasia G GoumenouAydin Arici

Abstract

To investigate the expression of p16, retinoblastoma (pRb), and cyclin D1 oncoproteins in endometriomas and adenomyosis. Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues. University hospital. Tissues from 25 women with endometriomas and 31 women with adenomyosis were evaluated. Tissue samples were collected during gynecologic surgery and confirmed by histology to have endometriosis or adenomyosis. Nuclear expression of p16, pRb, and cyclin D1 proteins was examined by immunohistochemistry. Distribution and intensity of immunostaining. In the proliferative phase of the cycle, p16 was detected in 77% of adenomyosis tissues but in only 15% of endometriosis tissues. Moreover, in adenomyosis samples positive for p16, 100% of the adenomyotic cells expressed p16, whereas only 10%-20% of endometriosis cells from positive cases expressed p16. In contrast, pRb was detected in 28% of endometriosis cases but not in any adenomyotic tissues. Cyclin D1 was absent in both endometriotic and adenomyotic tissue samples. Differences in oncoprotein expression between endometriotic and adenomyotic tissues provide further evidence that the pathogenesis of endometri...Continue Reading

References

Feb 1, 1995·Journal of Assisted Reproduction and Genetics·A BukovskyS E van Meter
Nov 24, 1998·Human Reproduction Update·A Ferenczy
Mar 10, 1999·Virchows Archiv : an International Journal of Pathology·K Milde-LangoschT Löning
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Dec 13, 2003·Cancer Letters·Andrzej Semczuk, Jerzy Andrzej Jakowicki
Jan 28, 2004·Cell·Charles J Sherr
Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Rajesh VarmaEamonn R Maher
Dec 14, 2004·Gynecologic Oncology·Barbara Bodner-AdlerKlaus Mayerhofer

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Citations

Oct 12, 2010·Molecular Human Reproduction·Zhen Zhen ZhaoGrant W Montgomery
Apr 13, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·B BorgheseC Chapron
Jan 24, 2007·Fertility and Sterility·Xishi Liu, Sun-Wei Guo
Dec 28, 2019·Human & Experimental Toxicology·A KaramianM G Novin
Apr 17, 2019·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos
Mar 31, 2017·Biomedical Reports·Saeedeh SalimiMinoo Yaghmaei
Jul 6, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F M AraujoA A Nogueira
Nov 1, 2018·Reproductive Medicine and Biology·Sun-Wei Guo

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