PMID: 9159345May 1, 1997Paper

p16INK4 and p15INK4B alterations in primary gynecologic malignancy

Gynecologic Oncology
Y F WongA M Chang

Abstract

Chromosome 9 abnormalities have been found in primary tumors and cell lines from human gynecologic malignancy. Alterations of p16INK4 and p15INK4B genes mapped on the band p21 of chromosome 9 have been detected in various human tumors, but the role of these genes as tumor suppressors in vivo appear to be dependent on tumor type. Polymerase chain reaction (PCR)-based analysis was performed to search for lesions of these genes in 202 primary gynecologic malignancies. Homozygous deletions of p16INK4 were detected in 7 of 128 (5%) cervical, 1 of 41 (2%) endometrial, 2 of 27 (7%) ovarian, and 3 of 6 (50%) vulvar carcinomas, while homozygous deletions of p15INK4B were detected in 19 of 128 (15%) cervical, 1 of 41 (2%) endometrial, 9 of 27 (33%) ovarian, and 3 of 6 (50%) vulvar carcinomas, respectively. No mutations were found in exon 2 of p16INK4 from 161 cases of gynecologic malignancy without deletion of p16INK4. All 3 cases of vulvar carcinoma showing homozygous deletions of p16INK4 and p15INK4B were at advanced clinical stage (stage III-IV), while all 7 cases of cervical carcinoma and 2 cases of ovarian carcinoma showing homozygous deletion of p16INK4 were at early stage (stage I-II). The results indicate that homozygous deletion...Continue Reading

References

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Citations

Feb 14, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Helga B Salvesen, Lars A Akslen
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Feb 22, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lakshmi Sowjanya BammidiRudrama Devi Kanapuram
Jun 17, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Suki KangNam Hoon Cho
Feb 22, 2005·International Journal of Cancer. Journal International Du Cancer·Helga B SalvesenLars A Akslen
Feb 27, 2010·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Yara L FurtadoMaria da Gloria Carvalho
Jul 17, 1999·British Journal of Cancer·R NakashimaY Murata
Jan 12, 2011·Nature Reviews. Clinical Oncology·Konstantin J DedesJorge S Reis-Filho
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Apr 20, 2019·International Journal of Cancer. Journal International Du Cancer·Jorge L SepulvedaAntonia R Sepulveda
Dec 13, 2003·Cancer Letters·Andrzej Semczuk, Jerzy Andrzej Jakowicki

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