p16INK4a overexpression independent of human papillomavirus infection in lobular endocervical glandular hyperplasia

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Akihiko HashiKazuhiko Hoshi

Abstract

A high rate of human papillomavirus (HPV) infection has been reported in cervical cancer and precancerous lesions. Many studies also have shown that p16INK4a overexpression is of diagnostic value for high-risk HPV-related cervical cancer and precursors. Lobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. There is one report about HPV infection and few studies on p16INK4a expression in LEGH. Therefore, we 1) detected HPV infection and examined p16INK4a expression and 2) observed the relationship between HPV and p16INK4a overexpression in LEGH. The immunohistochemical expression of p16INK4a was studied in 24 cases of LEGH. HPV DNA was also evaluated in these cases using a polymerase chain reaction technique. Strong (++) p16INK4a immunoreactivity was observed in 10 (41.7%) of the 24 LEGH cases; a moderate (+) pattern was observed in 9 (37.5%) cases; a weak (+) pattern was observed in 2 (8.3%) cases; and the remaining 3 (12.5%) cases showed negative expression. Overall, p16INK4a overexpression was seen in 87.5% of the cases (21/24). HPV DNA was not detected in any of the 24 LEGH cases. These results suggest that p16INK4a overexpression is independent of HPV infection in LEGH.

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Citations

Feb 4, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michael H RohChristopher P Crum
Aug 22, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Khush Mittal
Apr 1, 2014·Archives of Pathology & Laboratory Medicine·Joana Loureiro, Esther Oliva
Mar 1, 2011·Surgical Pathology Clinics·Kay J Park
Aug 19, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alaa A El-GhobashyC Simon Herrington
Jun 29, 2011·Histopathology·Mona El-Bahrawy
Nov 11, 2009·Pathology·Nicholas J MulvanyDavid G Allen
Mar 17, 2007·Pathology·W Glenn McCluggage
May 1, 2008·Pathology·Nicholas J MulvanySharyn M Wilson
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Khush MittalW G McCluggage

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