p16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem

Virchows Archiv : an International Journal of Pathology
N MurphyJ J O'Leary

Abstract

A wide array of immunohistochemical markers have been evaluated with respect to their specificity in staining dysplastic cervical cells in cervical biopsies and cervical cytological smears. However, there is still a significant demand for better biomarkers to identify neoplastic cervical glandular and squamous epithelial cells precisely. The CDKN2A gene, located on chromosome 9p21, encodes the tumour suppressor protein, p16INK4A, which decelerates the cell cycle by inactivating CDK4 and CDK6. The aim of this study was to compare and contrast the expression pattern of p16INK4A in benign and neoplastic glandular lesions and tubo-endometrioid metaplasia. All cases in each category displayed some p16INK4A expression. Adenocarcinoma and in situ cases showed a combination of intense nuclear and cytoplasmic staining. It was observed that all cases of tubo-endometrioid metaplasia showed occasional nuclear positivity and definite cytoplasmic staining. These findings may have important implications for the potential utility of p16INK4A as a biomarker for glandular dysplastic lesions. While p16INK4A has been demonstrated to be an excellent marker of cervical dysplasia in squamous neoplastic lesions of the cervix, it has potential pitfalls...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J W FountainJ Lahti
Jan 1, 1992·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·J G JonassonB S Ducatman
Oct 1, 1990·The American Journal of Surgical Pathology·G H Segal, W R Hart
Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K S Suh, S G Silverberg
Dec 1, 1986·American Journal of Epidemiology·S M Schwartz, N S Weiss
Feb 1, 1995·Genes, Chromosomes & Cancer·E HealyJ L Rees
Jul 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggageH Bharucha
Jan 1, 1997·Revista da Associação Médica Brasileira·T Marques, L A Andrade
Aug 15, 1998·American Journal of Clinical Pathology·N S GoldsteinN Perez-Reyes
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·G H WilliamsN Coleman
Jun 4, 1999·Cancer Letters·Y F WongA M Chang
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R J Zaino
Nov 30, 2000·Virchows Archiv : an International Journal of Pathology·L RiethdorfC P Crum
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Jan 16, 2002·Disease Markers·M von Knebel Doeberitz
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Kazuya KudohKazuhiko Uchida
Oct 16, 2002·Human Pathology·Lutz RiethdorfChristopher P Crum
Mar 1, 2003·Journal of Clinical Pathology·W G McCluggage
Sep 1, 1953·Cancer·G H FRIEDELL, D G McKAY

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Citations

May 2, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michelle Reid-NicholsonRobert A Soslow
Jun 11, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mohammad ArafaPhilippe Delvenne
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Marina ChekmarevaEdyta C Pirog
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Souzan SanatiLourdes R Ylagan
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kate Cuschieri, Nicolas Wentzensen
Apr 1, 2014·Archives of Pathology & Laboratory Medicine·Joana Loureiro, Esther Oliva
Oct 23, 2012·American Journal of Clinical Pathology·Alberto RavarinoGiovanni Negri
Apr 5, 2008·Gynecologic Oncology·Brigitte SamamaNelly Boehm
Mar 6, 2009·Veterinary Ophthalmology·Heather L ChandlerCarmen M H Colitz
Jun 29, 2011·Histopathology·Mona El-Bahrawy
May 1, 2008·Pathology·Nicholas J MulvanySharyn M Wilson
Sep 16, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sonia AnderssonBo Johansson
Nov 2, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sandra LeeMáire A Duggan
Nov 11, 2009·Pathology·Nicholas J MulvanyDavid G Allen
Jan 18, 2018·International Journal of Cancer. Journal International Du Cancer·Kate CuschieriSilvia Franceschi
Nov 1, 2005·Yonsei Medical Journal·Young Tae Kim, Min Zhao
Feb 8, 2006·Advances in Anatomic Pathology·Ciaran J O'Neill, W Glenn McCluggage
Jul 10, 2012·Virchows Archiv : an International Journal of Pathology·Suzuko MoritaniSteven G Silverberg
Jun 6, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sandra LeeMáire A Duggan
Apr 4, 2009·Physiological Measurement·Stephen J PreeceRobin Crompton
Feb 13, 2007·International Journal of Cancer. Journal International Du Cancer·Constance MaoLaura A Koutsky

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