P2 receptors and chronic pain.

Purinergic Signalling
Kazuhide Inoue

Abstract

There is abundant evidence that extracellular ATP and other nucleotides have an important role in pain signaling at both the periphery and in the CNS. The focus of attention now is on the possibility that endogenous ATP and its receptor system might be activated in chronic pathological pain states, particularly in neuropathic and inflammatory pain. Neuropathic pain is often a consequence of nerve injury through surgery, bone compression, diabetes or infection. This type of pain can be so severe that even light touching can be intensely painful; unfortunately, this state is generally resistant to currently available treatments. In this review, we summarize the role of ATP receptors, particularly the P2X₄, P2X₃ and P2X₇ receptors, in neuropathic and inflammatory pain. The expression of P2X₄ receptors in the spinal cord is enhanced in spinal microglia after peripheral nerve injury, and blocking pharmacologically and suppressing molecularly P2X₄ receptors produce a reduction of the neuropathic pain behaviour. Understanding the key roles of these ATP receptors may lead to new strategies for the management of intractable chronic pain.

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Citations

Jul 2, 2008·Nature Reviews. Drug Discovery·Geoffrey Burnstock
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
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Jan 20, 2011·The Journal of Biological Chemistry·Esperanza JiménezBeatriz López-Corcuera
Oct 6, 2020·Purinergic Signalling·Kazuhide Inoue
Jan 19, 2021·Injury·Hikaru HayakawaToshihiko Yamashita

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Methods Mentioned

BETA
antisense oligodeoxynucleotide

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