P2 receptors in atherosclerosis and postangioplasty restenosis.

Purinergic Signalling
C I SeyeGary A Weisman

Abstract

Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [1-3]. Extracellular nucleotides that are released from a variety of arterial and blood cells [4] can bind to P2 receptors and modulate proliferation and migration of smooth muscle cells (SMC), which is known to be involved in intimal hyperplasia that accompanies atherosclerosis and postangioplasty restenosis [5]. In addition, P2 receptors mediate many other functions, including platelet aggregation, leukocyte adherence, and arterial vasomotoricity. A direct pathological role of P2 receptors is reinforced by recent evidence showing that up-regulation and activation of P2Y(2) receptors in rabbit arteries mediates intimal hyperplasia [6]. In addition, up-regulation of functional P2Y receptors also has been demonstrated in the basilar artery of the rat double-hemorrhage model [7] and in coronary arteries of diabetic dyslipidemic pigs [8]. It has been proposed that up-regulation of P2Y receptors may be a potential diagnostic indicator for the early stages of atherosclerosis [9]. Therefore, particular effort must be made to understand the consequenc...Continue Reading

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Citations

May 8, 2007·Journal of Pharmaceutical and Biomedical Analysis·Cleber A TrujilloHenning Ulrich
Jul 2, 2009·Autonomic & Autacoid Pharmacology·G Burnstock
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Geoffrey Burnstock
Sep 23, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kieran QuinnHaibo Zhang
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic

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Methods Mentioned

BETA
immunoprecipitation

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