P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration

The Journal of Surgical Research
Bao SongZhongfa Xu

Abstract

P21-activated kinases (PAKs) are small guanosine triphosphate effectors that play critical roles in many fundamental cellular functions, including cytoskeletal reorganization and cell motility. PAKs are widely expressed in a variety of tissues and are often overexpressed in multiple cancer types. The aim of this study was to investigate the relationship between PAK1 and PAK4 and clinicopathologic features of colorectal cancer. PAK1 and PAK4 expression in colorectal cancer patients were investigated via TaqMan real-time polymerase chain reaction and immunohistochemistry and clinical analysis. The relative expression levels of PAK1 and PAK4 gene in colorectal carcinoma tissues were significantly higher than those in normal tissues (P < 0.01). PAK4 expression was higher than PAK1 in the same cancer tissue. The expression of PAK1 and PAK4 increased gradually with the clinical stages in carcinoma tissues (P < 0.01). PAK1 expression was higher in lymph node positive patients, and PAK4 expression was higher in infiltration into serous layer patients (P < 0.05). PAK1 overexpression group has a higher recurrence/metastasis rate compared with that of the PAK1 low expression group. Follow-up analysis showed that the median progression-fre...Continue Reading

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Citations

May 26, 2017·Cell Death & Disease·Xiumei ZhangFeng Li
May 31, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sehhoon ParkHo-Seong Han
Mar 18, 2020·Cancers·Larissa Kotelevets, Eric Chastre
Apr 24, 2019·Geriatrics·Kyle DammannChristoph Gasche
Jan 27, 2016·World Journal of Gastroenterology : WJG·Yang-Guang ShaoFeng Li
Jul 6, 2017·Oncology Reports·Xianghe LuWenfeng Li
Feb 26, 2019·Clinical Medicine Insights. Oncology·Nikolaos SymeonidisConstantinos Simopoulos
Nov 20, 2019·Bioorganic & Medicinal Chemistry Letters·Ruijuan LiMaosheng Cheng

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