PMID: 9552411Jan 1, 1997Paper

p21: structure and functions associated with cyclin-CDK binding

Progress in Cell Cycle Research
K L Ball

Abstract

The cyclin dependent kinase inhibitor, p21, is a multifunctional protein involved in coordinating the cellular response to negative growth signals. Induced by cellular damage under the transcriptional control of the p53 tumour suppressor protein, p21 interfaces with a number of cellular proteins involved in growth control. Although p21 has a diverse range of activities, from assembly factor to transcriptional modulator, its ability to interact with and regulate the activity of the cyclin dependent protein kinases is paramount to many of these functions.

Citations

Mar 29, 2002·The Journal of Biological Chemistry·David M LoebSaraswati Sukumar
Mar 22, 2001·Radiation Research·J SavellW Wharton
Sep 13, 2005·Oncogene·Susan J Marriott, Oliver John Semmes
Jun 3, 2020·Genes·Sabrina Florencia MansillaVanesa Gottifredi
Jun 1, 2004·Molecular and Cellular Biology·Maura Wallace, Kathryn L Ball
Sep 8, 2007·Antioxidants & Redox Signaling·Alicja JozkowiczJozef Dulak
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