Abstract
As the main downstream effecter of tumor suppressor p53, p21(Waf1/Cip1) functions as a unique link from p53 to cell-cycle arrest and DNA repair. In contrast to p53, p21(Waf1/Cip1) has general rare mutations. The natural genetic variants of p21(Waf1/Cip1) have thus emerged for study to enhance understanding of interindividual differences in cancer risk. Two polymorphisms in the p21 ( Waf1/Cip1 ) gene, i.e., codon 31 in the coding region and IVS2+16 in intron 2, have been identified and appeared to influence the expression of p21(Waf1/Cip1). The aim of this study is to investigate the potential association of the above two variants, including one new single-nucleotide polymorphism (SNP) 309 in the promoter region of p21 ( Waf1/Cip1 ), with susceptibility to esophageal cancer (EC). The study involved 80 cancer patients and 200 cancer-free controls from Ningxia Region of China. Three variations (codon 31, IVS2+16, and SNP 309) were identified by polymerase chain reaction (PCR) direct sequencing method, and associations of each individual SNP and haplotypes of the three SNPs with esophageal cancer were analyzed. The correlation results supported that codon 31 Ser homozygosity conferred risk for the process of developing EC [odds rat...Continue Reading
References
Apr 1, 1995·Human Genetics·J C Law, A Deka
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Aug 1, 1996·Molecular Carcinogenesis·L A TerryJ C Barrett
Feb 3, 2000·Oncogene·R BahlR Ralhan
Mar 15, 2001·Cancer Letters·J RohH Lee
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 23, 2002·Journal of Clinical Laboratory Analysis·Ming-Hsui TsaiFuu-Jen Tsai
Sep 13, 2002·Journal of Medical Virology·Zhong-Ying ShenYi Zeng
Oct 26, 2002·Oncogene·Ya-Guang XiYang Ke
Nov 11, 2003·Cancer Letters·Ming-Tsang WuJang-Ming Lee
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Jan 9, 2004·Cell Cycle·Rati FotedarArun Fotedar
Apr 22, 2004·Gynecologic Oncology·Ju Won RohHyo Pyo Lee
Jul 9, 2004·Carcinogenesis·Ya-Guang XiYang Ke
Dec 29, 2004·Surgery Today·Hiroyuki KuwanoAhmad Faried
Mar 19, 2005·Carcinogenesis·Bangwei CaoYang Ke
Sep 16, 2005·The New England Journal of Medicine·Jiang HePaul K Whelton
Mar 22, 2006·Oncogene·E C PietschM E Murphy
Oct 25, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Odilia PopandaPeter Schmezer
Nov 30, 2007·Journal of Human Genetics·Yi Young ChoiJae Yong Park
Mar 31, 2009·Gastroenterology Clinics of North America·Winson Y Cheung, Geoffrey Liu
Citations
May 14, 2014·PloS One·Liang ZhengHaiyong Gu
Dec 18, 2013·Indian Journal of Human Genetics·Praveen Kumar JaiswalRama Devi Mittal
Mar 29, 2011·Chinese Journal of Cancer·Hongxia MaQingyi Wei
Mar 8, 2011·Archives of Toxicology·Klaus GolkaJan G Hengstler
Mar 19, 2011·Mutagenesis·Fei LiuTianfu Wen
Feb 26, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Anja SchützAndreas Kolk
Oct 5, 2012·International Journal of Cancer. Journal International Du Cancer·Fei LiuBo Li
Mar 5, 2016·Scientific Reports·Wenjun YangYang Ke
Jun 18, 2011·American Journal of Rhinology & Allergy·Sun-Gui KimKi-Sang Rha
Mar 25, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ya LiShangwei Li
Jan 8, 2013·Molecular Medicine Reports·Monika Kmetová SivoňováJán Kliment
Jan 9, 2015·Genes & Cancer·Zhifeng NingHao Zhang
Aug 24, 2019·Cancers·Nina-Naomi KreisJuping Yuan