PMID: 9448297Mar 14, 1998Paper

p21WAF-1 reorganizes the nucleus in tumor suppression

Proceedings of the National Academy of Sciences of the United States of America
G Linares-CruzA Telerman

Abstract

Interphasic nuclear organization has a key function in genome biology. We demonstrate that p21WAF-1, by influencing gene expression and inducing chromosomal repositioning in tumor suppression, plays a major role as a nuclear organizer. Transfection of U937 tumor cells with p21WAF-1 resulted in expression of the HUMSIAH (human seven in absentia homologue), Rb, and Rbr-2 genes and strong suppression of the malignant phenotype. p21(WAF-1) drastically modified the compartmentalization of the nuclear genome. DNase I genome exposure and fluorescence in situ hybridization show, respectively, a displacement of the sensitive sites to the periphery of the nucleus and repositioning of chromosomes 13, 16, 17, and 21. These findings, addressing nuclear architecture modulations, provide potentially significant perspectives for the understanding of tumor suppression.

References

Sep 1, 1991·Somatic Cell and Molecular Genetics·T T PuckM Haag
Dec 14, 1990·Science·L Manuelidis
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R BooksteinW H Lee
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·T CremerP Lichter
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·J B LawrenceX Xing
Dec 1, 1993·Current Opinion in Cell Biology·R M Krug
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 16, 1993·Nature·Y XiongD Beach
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A TelermanR Amson
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·R B AmsonA Telerman
Jul 12, 1996·Cell·G Felsenfeld
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M NemaniA Telerman
Apr 1, 1997·Current Opinion in Genetics & Development·W F MarshallJ W Sedat

❮ Previous
Next ❯

Citations

Sep 28, 2007·Comprehensive Therapy·Ugochi Ajulaoke Erondu, Tyler Childs Cymet
Jun 1, 2005·Biochemical and Biophysical Research Communications·Hyunju RoMyungchull Rhee
Nov 20, 1998·Trends in Genetics : TIG·J M Bridger, W A Bickmore
Nov 18, 2010·Journal of Proteome Research·Feng GeLi-Jun Bi
Dec 14, 2011·Nature Medicine·Robert AmsonAdam Telerman
Jan 31, 2009·Nature Reviews. Cancer·Adam Telerman, Robert Amson
Nov 17, 2006·Molecular Biology of the Cell·Patricia C AbadSophie A Lelièvre
Nov 21, 2012·Current Opinion in Oncology·Robert AmsonAdam Telerman
Jul 18, 2002·Annals of the New York Academy of Sciences·Theodore T PuckRobert Johnson
May 18, 2007·Journal of Virology·Christel MassonJean-François Mouscadet
Nov 6, 2002·Molecular and Cellular Biology·Ian J FrewDavid D L Bowtell
Mar 9, 2002·Molecular and Cellular Biology·Ross A DickinsDavid D L Bowtell
Feb 11, 2010·Journal of Experimental & Clinical Cancer Research : CR·Heriberto Bruzzoni-GiovanelliMónica Marín
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·R AmsonA Telerman
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Giusy FiucciAdam Telerman
Sep 7, 2014·Neurotoxicology and Teratology·Haijing SunShao-Yu Chen
Nov 6, 2012·Trends in Cell Biology·Robert AmsonAdam Telerman
Jun 20, 2007·Experimental Hematology·Gregor A Prindull, Eitan Fibach
Oct 10, 2006·DNA Repair·Louise J Barber, Simon J Boulton
Nov 19, 2003·Mechanisms of Development·Wallace F Marshall
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philippe RouanetThierry Maudelonde
Dec 5, 2003·Oncogene·Antonia GermaniHeriberto Bruzzoni-Giovanelli
Dec 22, 1999·Oncogene·H Bruzzoni-GiovanelliF Calvo
Feb 20, 2002·FEBS Letters·Ayaka MaedaToshiyuki Sakai
Mar 20, 2001·Nature Reviews. Molecular Cell Biology·C FrancastelM Groudine
Oct 26, 2000·Nature·T RichA H Wyllie
Jul 26, 2002·The Journal of Biological Chemistry·Qun WuSuxing Liu
Mar 30, 1999·Experimental Cell Research·F D Coffman, G P Studzinski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M NemaniA Telerman
Proceedings of the National Academy of Sciences of the United States of America
A TelermanR Amson
© 2021 Meta ULC. All rights reserved