p27 -V109G Polymorphism Is Not Associated with the Risk of Prostate Cancer: A Case-Control Study of Han Chinese Men in Central China

Disease Markers
Meng ZhangChaozhao Liang

Abstract

We conducted an update meta-analysis aiming to verify the association between p27-V109G polymorphism and cancer risk, particular for prostate cancer (PCa). Then, we conducted a case-control study of Han Chinese in central China to verify the evidence-based results. Relevant studies were collected from diverse databases up to March 2017. In addition, a hospital-based (H-B) case-control study enrolling 90 PCa patients and 140 healthy controls was included to verify these evidence-based findings. Genetic risk was calculated by odds ratio (OR) with its corresponding 95% confidence interval (CI). The p27-V109G polymorphism was determined by MassARRAY genotyping method. Finally, twenty-four published studies comprising 9627 cases and 12,102 controls were enrolled for the current meta-analysis. Overall analysis suggested that p27-V109G polymorphism decreased overall cancer risk in allelic contrast, heterozygote, and dominant models. When stratified analysis was conducted by ethnicity, data revealed that p27-V109G polymorphism was associated with a decreased cancer risk in Caucasians. Highlighted in the subgroup analysis by cancer type, we uncovered a significantly decreased risk of PCa in allelic contrast, dominant, homogeneous, and r...Continue Reading

References

Feb 23, 1999·The American Journal of Pathology·R V LloydB W Scheithauer
Dec 19, 2003·Breast Cancer Research : BCR·Angel Alkarain, Joyce Slingerland
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guojun LiQingyi Wei
Jan 4, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Thomas SchöndorfMarkus Hoopmann
May 5, 2006·BMC Cancer·Venüs Ummiye OnayHilmi Ozcelik
Jun 29, 2006·International Journal of Cancer. Journal International Du Cancer·Hongxia MaHongbing Shen
Apr 6, 2007·Cancer Research·Simon A GaytherUNKNOWN Ovarian Cancer Association Consortium
Jun 15, 2007·BMC Cancer·Jane C FigueiredoHilmi Ozcelik
Jan 5, 2008·Carcinogenesis·Kristy E DriverUNKNOWN Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) Team
Jul 23, 2008·Urologia Internationalis·Shu-Pin HuangMing-Tsang Wu
Feb 19, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jian-Ling BaiFeng Chen
Dec 24, 2010·European Journal of Endocrinology·Daniela PasqualiVittorio Colantuoni
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 4, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Mohammad Reza SafarinejadShiva Safarinejad
May 10, 2011·International Journal of Biological Sciences·Shui-Long GuoXiao Yang
Jul 25, 2012·Cancer Biotherapy & Radiopharmaceuticals·Feng WeiXiaoxiang Guan
Oct 5, 2012·International Journal of Cancer. Journal International Du Cancer·Fei LiuBo Li
Jan 2, 2013·Molecular Biology Reports·Faten Zahran MohamedNoha Mohamed Said
Feb 18, 2014·Endocrine-related Cancer·Tomoko SekiyaRodrigo A Toledo
Jun 21, 2014·The British Journal of Oral & Maxillofacial Surgery·Abitha MuraliS Kannan
Jul 30, 2014·American Journal of Obstetrics and Gynecology·Prasad L GawadeKirsten K Ness
Aug 16, 2015·Asian Pacific Journal of Tropical Medicine·Qian-He HanXue-Pei Zhang
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Nuntiput PutthanachoteTony Hsiu-Hsi Chen
Feb 18, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Géssica LimaPaulo Souza
Oct 16, 2016·Oncotarget·Ming-Jie WangHui Zhao
Nov 12, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Amir HossainMd Mustafizur Rahman
Dec 22, 2017·Asian Journal of Urology·Kai ZhangMonique J Roobol
Dec 22, 2017·Asian Journal of Urology·Yoshiyasu AmiyaJun Shimazaki

❮ Previous
Next ❯

Citations

Feb 18, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·María S Jaureguiberry, Andrés Venturino
Jul 2, 2019·Journal of Cellular Biochemistry·Lijie ZhuLi Zuo

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

Assay Design
STATA
Google Scholar
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.