PMID: 7541920May 1, 1995Paper

P2X receptors bring new structure to ligand-gated ion channels

Trends in Neurosciences
A SurprenantR A North

Abstract

P2X receptors are cation-selective ion channels that open on binding to extracellular ATP; they play a role in fast synaptic transmission between neurones, and from autonomic nerves to smooth muscles. Isolation of cDNAs that encode P2X receptors in the smooth muscle of vas deferens and in phaeochromocytoma cells indicates that the receptors are not related to other ligand-gated ion channels. Their overall structure resembles more closely that of epithelial Na+ channels and the proteins that are thought to form mechanosensitive channels in Caenorhabditis elegans. The type of P2X RNA that is found in vas deferens is expressed preferentially by apoptotic thymocytes, and the type of P2X RNA that is found in PC12 cells is abundant in the pituitary gland, suggesting hitherto unsuspected roles for ATP-gated channels in endocrine and immune function.

References

Jul 1, 1978·The Journal of Physiology·G D Hirst, T O Neild
Jun 11, 1992·Nature·R J EvansA Surprenant
Mar 1, 1992·Trends in Pharmacological Sciences·B P Bean
Jan 1, 1992·Trends in Neurosciences·M Driscoll, M Chalfie
Apr 1, 1992·The Journal of Physiology·P Vincent
Sep 1, 1992·Journal of Neurophysiology·S UenoN Akaike
Aug 1, 1991·Molecular and Cellular Biology·G P OwensJ J Cohen
Nov 1, 1990·Trends in Biochemical Sciences·M SarasteA Wittinghofer
Jan 1, 1990·Annals of the New York Academy of Sciences·C D Benham
May 1, 1990·Journal of Neurophysiology·T NakagawaT Arima
Aug 1, 1987·Pflügers Archiv : European journal of physiology·K Nakazawa, N Matsuki
Jan 1, 1987·Progress in Neurobiology·M L Mayer, G L Westbrook
Dec 1, 1988·British Journal of Pharmacology·O A KrishtalT M Volkova
Feb 1, 1988·British Journal of Pharmacology·P M Dunn, A G Blakeley
Aug 25, 1983·Nature·C E Jahr, T M Jessell
Oct 1, 1994·Trends in Neurosciences·H Zimmermann
Jun 28, 1993·FEBS Letters·F A Edwards, A J Gibb
Jul 1, 1993·Pflügers Archiv : European journal of physiology·R ClouesD A Brown
Jan 1, 1994·Pharmacology & Therapeutics·M P Abbracchio, G Burnstock
Sep 1, 1994·British Journal of Pharmacology·J M LangoschP Illes
Apr 1, 1994·Current Biology : CB·P W Ingham
Mar 1, 1994·British Journal of Pharmacology·A U ZiganshinG Burnstock
Jan 1, 1994·General Pharmacology·F M Reekie, G Burnstock
Apr 1, 1994·Biophysical Journal·L HeginbothamR MacKinnon
Sep 8, 1994·Nature·L Y Jan, Y N Jan
Mar 1, 1994·Trends in Pharmacological Sciences·E A BarnardT E Webb

❮ Previous
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Citations

Sep 1, 2000·Drug Development Research·Liping ChenKenneth A Jacobson
Apr 29, 1998·Molecular Neurobiology·G D Housley
May 12, 2006·Pflügers Archiv : European journal of physiology·R Alan North, Alexei Verkhratsky
Apr 12, 2006·Pflügers Archiv : European journal of physiology·Jonathan A RobertsRichard J Evans
Apr 30, 2008·Purinergic Signalling·Manuela MoratoAntónio Albino-Teixeira
Nov 1, 2011·Purinergic Signalling·Chiara ManganoBjörn Meister
Jan 18, 1996·European Journal of Pharmacology·K Nakazawa, Y Ohno
Feb 2, 1996·Neuroscience Letters·C Balachandran, M R Bennett
Jul 19, 1996·Neuroscience Letters·T Nishimura, T Tokimasa
Jan 8, 2004·European Journal of Pharmacology·Peter Illes, J Alexandre Ribeiro
Apr 10, 2013·European Journal of Pharmacology·María G Nieto-PescadorCarlos Barajas-López
Nov 21, 1996·European Journal of Pharmacology·R FröhlichP Illes
Feb 5, 1997·European Journal of Pharmacology·I DobronyiM H Maguire
Apr 23, 1997·European Journal of Pharmacology·K Nakazawa, Y Ohno
Oct 6, 1998·European Journal of Pharmacology·J M SanzF Di Virgilio
Jun 28, 2000·Journal of the Autonomic Nervous System·B S Khakh, G Henderson
Jun 28, 2000·Journal of the Autonomic Nervous System·J J GalliganX Zhou
Dec 1, 1996·Progress in Neurobiology·M R Bennett
Mar 3, 1998·Progress in Neurobiology·P S GuthP Valli
Jul 31, 1998·Hearing Research·M S ParkerP L Deininger
Aug 1, 1996·Current Opinion in Cell Biology·R A North
Sep 7, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C A Nurse, M Zhang
Apr 1, 1997·British Journal of Pharmacology·L KhirougA Nistri

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