P2X2 receptors on ganglion and amacrine cells in cone pathways of the rat retina

The Journal of Comparative Neurology
T Puthussery, E L Fletcher

Abstract

Extracellular ATP is known to mediate fast, excitatory neurotransmission through activation of ionotropic P2X receptors. In this study, the localization of the P2X(2) receptor (P2X(2)R) subunit was studied in rat retina by using immunofluorescence immunohistochemistry and preembedding immunoelectron microscopy. The P2X(2)R was observed in large ganglion cells as well as in a subset of amacrine cells. Double labeling revealed that 96% of all P2X(2)R-immunoreactive amacrine cells showed gamma-aminobutyric acid (GABA) immunoreactivity. Subsets of P2X(2)R-immunoreactive amacrine cells expressed nitric oxide synthase and substance P; however, no colocalization was observed with choline acetyltransferase, vasoactive intestinal peptide, or tyrosine hydroxylase. Nearest-neighbor analysis confirmed that P2X(2)Rs were expressed by a heterogeneous population of amacrine cells. The synaptic connectivity of P2X(2)R amacrine cells was also investigated. It was interesting that P2X(2)R-immunoreactive amacrine cell dendrites stratified in the sublaminae of the inner plexiform layer occupied by cone, but not rod bipolar cell axon terminals. Immunoelectron microscopy revealed that P2X(2)-immunoreactive amacrine cell processes were associated wit...Continue Reading

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Citations

Aug 1, 2007·The Journal of General Physiology·Luciano Moffatt, Richard I Hume
Apr 8, 2014·Pflügers Archiv : European journal of physiology·Christian LohrDaniela Hirnet
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Jan 31, 2009·The Journal of Comparative Neurology·Theresa Puthussery, Erica Fletcher
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Mar 19, 2014·The Journal of Comparative Neurology·Kirstan A VesseyErica L Fletcher
Oct 19, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Tracy HoErica L Fletcher
Jul 1, 2016·Scientific Reports·Ping-Ping ZhangYong-Mei Zhong
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Oct 23, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Erica L Fletcher

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