P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases.

European Journal of Pharmacology
Abtar MishraRohan Dhiman

Abstract

P2X7 receptor, a purinergic receptor family member, is abundantly expressed on many cells, including immune, muscle, bone, neuron, and glia. It acts as an ATP-activated cation channel that permits the influx of Ca2+, Na+ and efflux of K+ ions. The P2X7 receptor plays crucial roles in many physiological processes including cytokine and chemokine secretion, NLRP3 inflammasome activation, cellular growth and differentiation, locomotion, wound healing, transcription factors activation, cell death and T-lymphocyte survival. Past studies have demonstrated the up-regulation and direct association of this receptor in many pathophysiological conditions such as cancer, diabetics, arthritis, tuberculosis (TB) and inflammatory diseases. Hence, targeting this receptor is considered a worthwhile approach to lessen the afflictions associated with the disorders mentioned above by understanding the receptor architecture and downstream signalling processes. Here, in the present review, we have dissected the structural and functional aspects of the P2X7 receptor, emphasizing its role in various diseased conditions. This information will provide in-depth knowledge about the receptor and help to develop apt curative methodologies for the betterment...Continue Reading

References

Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A FilippiniM V Sitkovsky
Jan 1, 1995·Progress in Nucleic Acid Research and Molecular Biology·A Gashler, V P Sukhatme
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Nov 19, 1997·Neuropharmacology·C VirginioA Surprenant
Apr 14, 1999·Cell Death and Differentiation·F Di VirgilioO R Baricordi
May 1, 1999·The Journal of Biological Chemistry·D FerrariK Schulze-Osthoff
Nov 24, 1999·The Journal of Biological Chemistry·O R BaricordiF Di Virgilio
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J Kusner, J Adams
May 24, 2000·British Journal of Pharmacology·A D MichelP P Humphrey
Oct 4, 2000·The Journal of Biological Chemistry·M SolleC A Gabel
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D G PerregauxC A Gabel
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D FerrariF Di Virgilio
Feb 24, 2001·Cellular Microbiology·P B Wyrick
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A GartlandW B Bowler
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B C SuhK T Kim
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L C DenlingerP J Bertics
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J Kusner, J A Barton
Dec 1, 2001·Immunity·A MacKenzieA Surprenant
Jun 18, 2002·Journal of Neurochemistry·Beáta SperlághE Sylvester Vizi
Aug 2, 2002·European Journal of Pharmacology·Rosalind Le FeuvreNancy Rothwell
Sep 25, 2002·Physiological Reviews·R Alan North
Dec 17, 2003·Journal of Neurochemistry·Christopher M AndersonRaymond A Swanson
Mar 6, 2004·Breast Cancer Research and Treatment·Michael SlaterJulian A Barden
Mar 23, 2004·Annals of the New York Academy of Sciences·Felix ScheupleinFriedrich Koch-Nolte
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas ElssnerMark D Wewers
Apr 13, 2004·American Journal of Physiology. Cell Physiology·J Michelle Kahlenberg, George R Dubyak
May 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna SoliniFrancesco Di Virgilio
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather L WilsonDavid C Crossman
Oct 8, 2004·American Journal of Physiology. Cell Physiology·R X FariaLuiz Anastácio Alves
May 18, 2005·Biochemical and Biophysical Research Communications·Boonlert CheewatrakoolpongScott Greenfeder

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Citations

Oct 10, 2021·Histochemistry and Cell Biology·Mariá Munhoz EvangelinellisPatricia Castelucci
Nov 30, 2021·IScience·Ross LuuEliseo Eugenin

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