P2X7 Receptor in the Management of Energy Homeostasis: Implications for Obesity, Dyslipidemia, and Insulin Resistance.

Frontiers in Endocrinology
Roberto Coccurello, Cinzia Volonté

Abstract

Whole-body energy metabolism entails the highly regulated balance between food intake, nutrient breakdown, energy generation (ATP), and energy storage for the preservation of vital functions and body mass. Purinergic signaling has attracted increasing attention in the regulatory mechanisms not only for the reverse processes of white adipose tissue lipogenesis and lipolysis, but also for brown adipocyte-dependent thermogenesis and leptin production. This regulatory role has remarkable implications in the handling of body's energy expenditure and energy reservoir. Hence, selected purinergic receptors can play a relevant function in lipid metabolism, endocrine activity, glucose uptake, ATP-dependent increased expression of uncoupling protein 1, and browning of adipose tissue. Indeed, purinergic P2 receptors regulate adipogenesis and lipid metabolism and are involved in adipogenic differentiation. In particular, the ionotropic ATP-activated P2X7 subtype is involved in fat distribution, as well as in the modulation of inflammatory pathways in white adipose tissue. Within this context, very recent evidence has established a direct function of P2X7 in energy metabolism. Specifically, either genetic deletion (P2X7 knockout mice) or sub...Continue Reading

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Citations

Mar 14, 2021·Pflügers Archiv : European journal of physiology·Andrea D RiveraArthur M Butt
May 18, 2021·Frontiers in Pharmacology·Vanni CarusoMaurizio Ronci
Dec 23, 2021·Experimental and Therapeutic Medicine·Jing LiQiaolan Xu
Sep 10, 2020·Biochemical Pharmacology·Miriane de OliveiraPaulo Correia-de-Sá

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