P300 amplitude as an indicator of externalizing in adolescent males.

Psychophysiology
Christopher J PatrickMatt McGue

Abstract

Reduced P300 amplitude is reliably found in individuals with a personal or family history of alcohol problems. However, alcoholism is part of a broader externalizing spectrum that includes other substance use and antisocial disorders. We hypothesized that reduced P300 is an indicator of the common factor that underlies disorders within this spectrum. Community males (N=969) were assessed at age 17 in a visual oddball task. Externalizing was defined as the common factor underlying symptoms of alcohol dependence, drug dependence, nicotine dependence, conduct disorder, and adult antisocial behavior. A robust association was found between reduced P300 amplitude and the externalizing factor, and this relation accounted for links between specific externalizing disorders and P300. Our findings indicate that reduced P300 amplitude is an indicator of the broad neurobiological vulnerability that underlies disorders within the externalizing spectrum.

Associated Clinical Trials

References

Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Jul 1, 1991·The Journal of Nervous and Mental Disease·T R KostenK Merikangas
Feb 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·D H BlackwoodA McInnes
Apr 1, 1988·Journal of Consulting and Clinical Psychology·R E Tarter
Dec 1, 1987·British Journal of Haematology·A N LestasA J Bellingham
Sep 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·Z WelnerH Amado
Oct 1, 1972·Archives of General Psychiatry·W T Roth, E H Cannon
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Sep 28, 1984·Science·H BegleiterB Kissin
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R ElmasianF Bloom
Aug 1, 1982·Archives of General Psychiatry·J F LeckmanM M Weissman
Jan 1, 1980·Advances in Experimental Medicine and Biology·B PorjeszR Garozzo
Mar 1, 1994·Electroencephalography and Clinical Neurophysiology·S O'ConnorT K Li
Dec 1, 1994·Alcoholism, Clinical and Experimental Research·L O BauerV M Hesselbrock
Jan 1, 1995·Archives of General Psychiatry·R J CadoretM A Stewart
Dec 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·S O'ConnorV Hesselbrock
Jan 1, 1993·Alcohol·S M BermanE P Noble
Jun 1, 1993·The Journal of Nervous and Mental Disease·S S LutharB J Rounsaville
Aug 1, 1995·Drug and Alcohol Dependence·R W PickensM C LaBuda
Jan 1, 1997·Psychophysiology·J KatsanisS R Carlson
Apr 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·D B ClarkP Ott
Apr 18, 1998·Journal of Affective Disorders·I YanaiY Touhouda
Apr 29, 1998·Biological Psychology·C E van BeijsterveldtD I Boomsma
Aug 26, 1998·Journal of Abnormal Psychology·W S SlutskeN G Martin
Jun 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L O Bauer, V M Hesselbrock
Aug 12, 1999·Alcoholism, Clinical and Experimental Research·H Begleiter, B Porjesz
Oct 26, 1999·Archives of General Psychiatry·R F Krueger
Nov 11, 1999·Psychophysiology·J M Ford
Jan 19, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·W Reich
Jun 23, 2000·Biological Psychiatry·L CostaH Begleiter
Jun 27, 2000·Psychopharmacology·A P AnokhinJ W Rohrbaugh

❮ Previous
Next ❯

Citations

May 29, 2012·Archives of General Psychiatry·Natalie SlopenCharles A Nelson
Mar 17, 2006·Current Psychiatry Reports·Jon A Frederick, William G Iacono
Jan 28, 2009·Psychological Medicine·J LobbestaelF Chakhssi
Oct 3, 2009·Psychological Medicine·R F Krueger, S C South
Jun 30, 2010·The Behavioral and Brain Sciences·Robert F KruegerKristian E Markon
May 9, 2012·Development and Psychopathology·Yawei ChengJean Decety
Jul 12, 2012·Development and Psychopathology·Christopher J PatrickJason S Moser
Nov 26, 2008·Journal of Abnormal Psychology·Scott R Carlson, William G Iacono
Sep 12, 2012·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Yu GaoSarnoff A Mednick
Oct 4, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Paul ZarkowskiJoan Russo
Apr 25, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher J Patrick
May 2, 2007·Psychological Science·Jason R HallChristopher J Patrick
Mar 29, 2008·Annual Review of Clinical Psychology·William G IaconoMatt McGue
Oct 7, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Margaret A KeyesWilliam G Iacono
May 12, 2007·Journal of Personality Disorders·Christopher J PatrickRobert F Krueger
Nov 5, 2013·Journal of Criminal Justice·James R YanceyChristopher J Patrick
Dec 18, 2013·Journal of Abnormal Child Psychology·Eleonora BertolettiMarco Battaglia
Nov 30, 2013·Addictive Behaviors·Melissa A Miller, Mark T Fillmore
Nov 3, 2010·Substance Use & Misuse·Nathaniel E AndersonMatthew S Stanford
Jan 13, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shirley Y HillScott Stiffler
May 10, 2011·Psychiatry Research·Cindy Louise EhlersDavid Austin Gilder
Oct 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Connie C DuncanCyma Van Petten
Jul 4, 2009·Clinical Psychology Review·M Catherine CappadociaJessica H Schroeder
May 6, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Lisa M Gatzke-KoppSidney J Segalowitz
Feb 7, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Arielle R Baskin-Sommers, Dan Foti
Jun 9, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Edward M BernatChristopher J Patrick
Mar 10, 2016·Journal of Personality Disorders·Laura E Drislane, Christopher J Patrick
Jun 30, 2009·Psychophysiology·Greg PerlmanWilliam G Iacono

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.