P300 as an index of transition to psychosis and of remission: Data from a clinical high risk for psychosis study and review of literature.

Schizophrenia Research
YingYing TangMargaret A Niznikiewicz

Abstract

Auditory P300 oddball and novel components index working memory operations and salience processing, respectively, and are regarded as biomarkers of neurocognitive changes in both chronic and first-episode schizophrenia. Much less is known about whether P300 abnormalities exist in individuals at clinical high risk for psychosis (CHR) and if they are predictors of both transition to psychosis and remission from symptoms. One hundred and four CHR and 69 healthy control individuals (HC) completed P300 oddball paradigm, and 131 CHR and 69 HC subjects completed P300 novel paradigm. All CHR subjects were followed up for one year and stratified into CHR converters (CHRC) and non-converters (CHR-NC), with CHR-NC further stratified into remitted and non-remitted subgroups. Between-group comparisons of P300 oddball and novel amplitude and latency were performed among CHRC, CHR-NC and HC, as well as among CHRC, non-remitted CHR, remitted CHR and HC. CHR converters had lower fronto-central P300 novel amplitude as well as marginally lower P300 oddball amplitude relative to HC. When CHR non-converters were stratified into remitted and non-remitted subgroups, P300 novel amplitude in remitted CHR subjects was comparable to HC, and it was higher...Continue Reading

References

Jan 1, 1996·Schizophrenia Bulletin·A R Yung, P D McGorry
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·D FriedmanH Gaeta
Dec 31, 2003·Psychophysiology·Yang-Whan Jeon, John Polich
Jun 10, 2005·Schizophrenia Research·Odin van der SteltAysenil Belger
Jun 19, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·John Polich
Dec 8, 2007·Nature Reviews. Drug Discovery·Daniel C JavittMihály Hajós
Apr 5, 2008·NeuroImage·Elvira BramonPhilip McGuire
Nov 8, 2008·Psychiatry Research·Bruce I TuretskyRaquel E Gur
Dec 17, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jijun WangHui Li
Jul 16, 2010·Biological Psychiatry·Mirjam J van TrichtDon H Linszen
Feb 9, 2011·Journal of Psychiatry & Neuroscience : JPN·Paolo Fusar-PoliPhilip McGuire
Apr 23, 2011·Schizophrenia Research·Rachel L LoewyTyrone D Cannon
May 4, 2011·Biological Psychology·Mirjam J van TrichtLieuwe de Haan
Jun 6, 2012·Archives of General Psychiatry·Paolo Fusar-PoliStefan Borgwardt
Mar 20, 2013·Journal of Psychiatric Research·Alejandra Mondragón-MayaCamilo de la Fuente-Sandoval
May 27, 2014·Frontiers in Behavioral Neuroscience·Yuko HiguchiTomiki Sumiyoshi
Jul 19, 2014·Biological Psychiatry·Tyrone D CannonUNKNOWN North American Prodrome Longitudinal Study Consortium
Jan 6, 2015·Psychiatry Research·Elisabetta C del ReMargaret A Niznikiewicz
Jul 2, 2016·The American Journal of Psychiatry·Tyrone D CannonMichael W Kattan
Mar 23, 2017·The American Journal of Psychiatry·Lisa M McTeagueAmit Etkin
Apr 5, 2017·Schizophrenia Research·Jean AddingtonScott W Woods

❮ Previous
Next ❯

Citations

Jan 13, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Holly K HamiltonDaniel H Mathalon
May 22, 2021·Frontiers in Psychiatry·Andrea PerrottelliArmida Mucci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.