P300-like potential disappears in rabbits with lesions in the nucleus basalis of Meynert

Experimental Brain Research
Y WangK Takahashi

Abstract

The nucleus basalis of Meynert (nbM, substantia innominata) in the basal forebrain provides a single major source of cholinergic innervation for the entire cerebral cortex. We tested the effects of nbM lesions on rabbit P300-like potentials. The P300-like event-related potential (ERP) was recorded in 14 female adult white rabbits using a conventional auditory oddball paradigm. The probability of occurrence for the 2-kHz and 1-kHz stimulus tones was 90% (frequent) and 10% (rare), respectively. The nbM was destroyed bilaterally in seven rabbits referred to as the nbM (+) group. In the other seven rabbits [nbM (-) group], putamen nuclei (n=6) or amygdaloid nuclei (n=1) were destroyed bilaterally. The evoked responses were recorded before and 1 week after the destruction. In the nbM (+) group, P300 amplitude to rare stimuli significantly decreased after the lesion. In the nbM (-) group, no component of ERPs showed changes after the lesions. These results indicate that the nbM might be involved in the generation of the rabbit P300.

Citations

Oct 1, 1999·Environmental Health and Preventive Medicine·J B PanK Morimoto
Sep 23, 2000·Behavioural Brain Research·L Zaborszky, A Duque
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H HörtnaglH Bubna-Littitz
Aug 3, 2005·Psychological Bulletin·Sander NieuwenhuisJonathan D Cohen
Sep 10, 2015·Psychophysiology·Stephen B R E BrownSander Nieuwenhuis
Sep 9, 2008·Journal of Theoretical Biology·J M ClearwaterP A Robinson
Feb 24, 2019·Journal of Neurosurgery·Darrin J LeeAndres M Lozano

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