P300 subcomponent abnormalities in schizophrenia: II. Longitudinal stability and relationship to symptom change

Biological Psychiatry
Bruce I TuretskyR E Gur

Abstract

Reduced amplitude of the P300 event-related brain potential (ERP) is a robust finding in schizophrenia. It remains unclear whether this represents a state or trait abnormality. We previously reported reductions of specific subcomponents of the auditory oddball P300 that were independent of acute symptomatology and were differentially associated with gender and deficit/nondeficit subtype. To clarify the state vs. trait nature of these abnormalities, we reassessed a subset of these patients after a minimum interval of 1 year following initial study. Auditory P300 ERPs were obtained from 18 patients at two time points and compared to baseline normative data recorded from 48 controls. Five P300 subcomponents were identified using current source density measures: frontal (P3f), bilateral parietal (P3pL, P3pR), and bilateral temporal (P3tL, P3tR). Patients exhibited reduced P300 amplitudes at baseline, including specific reductions of left temporal and right parietal subcomponents. There were no significant changes in P300 amplitudes over time, despite significant improvement in symptomatology, and the parietal subcomponent exhibited persistent impairment. There was, however, a trend toward normalization of the left temporal subcompo...Continue Reading

References

Apr 1, 1975·Electroencephalography and Clinical Neurophysiology·N K SquiresS A Hillyard
Nov 1, 1975·Electroencephalography and Clinical Neurophysiology·B Hjorth
Aug 1, 1992·The American Journal of Psychiatry·J M CleghornE S Garnett
Sep 1, 1990·Electroencephalography and Clinical Neurophysiology·M E SmithP Chauvel
Apr 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P B WardN McConaghy
Oct 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·J M CleghornP Cook
Nov 1, 1990·The American Journal of Psychiatry·P E BartaL E Tune
Aug 1, 1985·Electroencephalography and Clinical Neurophysiology·T GasserJ Möcks
Jul 1, 1987·Electroencephalography and Clinical Neurophysiology·J M Stapleton, E Halgren
Jan 1, 1989·Journal of Psychiatric Research·D St ClairW Muir
Feb 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·D H BlackwoodA McInnes
Jan 1, 1987·Schizophrenia Bulletin·P S Holzman
Sep 1, 1987·The International Journal of Neuroscience·J M StapletonE Halgren
Jan 1, 1986·Archives of General Psychiatry·F M BenesE D Bird
Oct 1, 1972·Archives of General Psychiatry·W T Roth, E H Cannon
Feb 1, 1984·Electroencephalography and Clinical Neurophysiology·C D Yingling, Y Hosobuchi
Oct 1, 1981·Annals of Neurology·M M Mesulam
Apr 1, 1995·Electroencephalography and Clinical Neurophysiology·P BaudenaJ M Clarke
Jan 1, 1993·Schizophrenia Bulletin·D L Braff

❮ Previous
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Citations

May 16, 2012·European Archives of Psychiatry and Clinical Neuroscience·Andres H NeuhausAnil K Malhotra
Feb 12, 2008·Neuroscience and Behavioral Physiology·I S LebedevaA N Barkhatova
Jan 23, 1999·Biological Psychiatry·E M LøbergM F Green
Mar 8, 2000·Biological Psychiatry·D H MathalonA Pfefferbaum
Dec 1, 2006·Schizophrenia Bulletin·Bruce I TuretskyNeal R Swerdlow
Mar 1, 2012·Schizophrenia Bulletin·Judith M FordRemko van Lutterveld
Dec 4, 2003·Biological Psychiatry·Georg WintererDaniel R Weinberger
Jul 20, 2014·Schizophrenia Research·Azurii K CollierRuben C Gur
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·T J MüllerW K Strik
May 3, 2008·Biological Psychology·Miriam CortiñasCarles Escera
Apr 23, 2004·Psychophysiology·Margaret A NiznikiewiczRobert W McCarley
Dec 31, 2003·Psychophysiology·Yang-Whan Jeon, John Polich
May 16, 2006·Psychiatry Research·Ingmar H A FrankenIlse M T Nijs
Oct 18, 2000·Biological Psychiatry·M A NiznikiewiczR W McCarley
Jul 6, 2010·Neuropsychologia·Lisa E WilliamsVilayanur S Ramachandran
Sep 22, 2001·Biological Psychiatry·G WintererD R Weinberger
Mar 23, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·E-Jin ParkYang-Whan Jeon
Sep 7, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Edward L MerrinPatricia A Lane
May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Milena KorostenskajaSeppo Kähkönen
Aug 12, 2010·Journal of Psychopharmacology·Matthew A AlbrechtRajan Iyyalol
Oct 17, 2017·Schizophrenia Bulletin·Holly K HamiltonDaniel H Mathalon
Jun 26, 2010·Current Protocols in Neuroscience·Gregory A LightDavid L Braff
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven J SiegelBruce I Turetsky
Aug 24, 2002·Clinical EEG (electroencephalography)·Daniel H Mathalon, Judith M Ford

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