p38 Kinase: A Key Target for Driving Potent T Cells for Adoptive Immunotherapy

Cancer Cell
Jack D ChanPhillip K Darcy

Abstract

In this issue of Cancer Cell, Gurusamy et al. use a CRISPR-Cas9 screening approach to demonstrate that deletion of p38 increases multiple phenotypic qualities of effective anti-tumor T cells. Preconditioning T cells with a p38 inhibitor enhances anti-tumor efficacy of adoptive immunotherapy.

References

Jun 16, 2009·Nature Medicine·Luca GattinoniNicholas P Restifo
Jun 1, 2018·Nature·Joseph A FraiettaJ Joseph Melenhorst
Dec 6, 2019·Nature·Rachel C LynnCrystal L Mackall
Feb 8, 2020·Science·Edward A StadtmauerCarl H June

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