PMID: 16627995Apr 22, 2006Paper

p38 MAPK in development and cancer

Cell Cycle
Cynthia Bradham, David R McClay

Abstract

p38 is a MAPK that has been shown to induce a wide variety of biological effects in cell culture in response to a wide range of stimuli. These effects are dependent not only on the stimuli, but also on the cellular context, resulting in a bewildering array of possibilities. For example, p38 was shown to induce apoptosis in some cells, but prevent apoptosis in others. Similarly opposed effects had been observed with respect to cell cycle regulation. The role of p38 in inflammatory disease has been appreciated from the beginning, since it was initially identified as an cytokine inducer. More recently, p38 function has been evaluated in vivo, and through these studies p38 has emerged as an important regulator of both embryonic development and cancer progression. This review will focus on these in vivo studies in an effort to provide perspective on p38 biologically and as a pharmacological target.

Citations

Jul 12, 2013·Cellular and Molecular Neurobiology·Zi-shu WangTao Chen
Sep 18, 2012·Journal of Computer-aided Molecular Design·Wee Kiang YeoShahul Nilar
Apr 5, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K GillS Dey
Jul 17, 2008·Nature Clinical Practice. Oncology·Giannis MountziosJean-Charles Soria
Aug 8, 2013·Nutrition and Cancer·Silvia Isabel Rech FrankeDaniel Prá
Nov 6, 2008·Pigment Cell & Melanoma Research·Yeriel EstradaLiliana Ossowski
Sep 15, 2011·Pigment Cell & Melanoma Research·Pablo Lopez-Bergami
Oct 7, 2011·Science Translational Medicine·Phuoc T TranDean W Felsher
Mar 3, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Derek WakemanBrad W Warner
Jun 22, 2012·Journal of Aging Research·Claus DeslerLene Juel Rasmussen
Aug 27, 2013·International Journal of Molecular Sciences·Ju-Hwa KimSungpil Yoon
Feb 12, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Hsien-Ming WuPeter C K Leung
May 18, 2011·Journal of Aging Research·Claus DeslerLene Juel Rasmussen
Oct 3, 2014·BioMed Research International·Siegfried WagnerIngo Nolte
May 31, 2013·Organic & Biomolecular Chemistry·Jia-Fei PoonPeter Dinér
Jun 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Yi GaoAn-Li Zhang
May 15, 2007·Oncogene·A S DhillonW Kolch
Oct 27, 2009·Expert Opinion on Investigational Drugs·Hae-Young YongAree Moon
Mar 1, 2016·Frontiers in Bioengineering and Biotechnology·Hilal Taymaz-NikerelBetul Kirdar
May 4, 2011·Differentiation; Research in Biological Diversity·Zongwei Wang, Aria F Olumi
Jun 28, 2011·Bioorganic & Medicinal Chemistry Letters·Alaric J DyckmanKaterina Leftheris
May 17, 2011·Experimental Gerontology·Zongli LiKewu Huang
Jul 1, 2015·Redox Biology·Gina MandaKemal Sami Korkmaz
Aug 12, 2009·Trends in Molecular Medicine·Lydia R CoulthardSusan A Burchill
Jul 18, 2009·The American Journal of Pathology·Xiao-Yang WangR Ilona Linnoila
Feb 27, 2007·Archives of Biochemistry and Biophysics·Stine Falsig PedersenMaria Rasmussen
Oct 24, 2006·Biochemical and Biophysical Research Communications·Hee-Sae ParkEui-Ju Choi

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