P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients

Frontiers in Psychiatry
Chen-Lan ShenHai-Gwo Hwu

Abstract

Sensory gating describes neurological processes of filtering out redundant or unnecessary stimuli during information processing, and sensory gating deficits may contribute to the symptoms of schizophrenia. Among the three components of auditory event-related potentials reflecting sensory gating, P50 implies pre-attentional filtering of sensory information and N100/P200 reflects attention triggering and allocation processes. Although diminished P50 gating has been extensively documented in patients with schizophrenia, previous studies on N100 were inconclusive, and P200 has been rarely examined. This study aimed to investigate whether patients with schizophrenia have P50, N100, and P200 gating deficits compared with control subjects. Control subjects and clinically stable schizophrenia patients were recruited. The mid-latency auditory evoked responses, comprising P50, N100, and P200, were measured using the auditory-paired click paradigm without manipulation of attention. Sensory gating parameters included S1 amplitude, S2 amplitude, amplitude difference (S1-S2), and gating ratio (S2/S1). We also evaluated schizophrenia patients with PANSS to be correlated with sensory gating indices. One hundred four patients and 102 control su...Continue Reading

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Citations

Apr 6, 2021·Neurophysiologie clinique = Clinical neurophysiology·Özge YükselayHüseyin Güleç
Sep 9, 2021·The European Journal of Neuroscience·Yingjun ZhengLiang Li

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