P50 sensory gating in panic disorder

Journal of Psychiatric Research
Eduardo S GhisolfiDiogo R Lara

Abstract

Previous studies with prepulse inhibition in panic disorder (PD) have suggested that the early stages of sensory information processing are abnormal in patients with PD. To further investigate sensory gating function in panic disorder we performed a case-control study in a sample of 28 patients with PD, compared to 28 normal subjects and 28 schizophrenic subjects evaluating auditory mid-latency evoked potential P50 in a double-click paradigm as a measure of sensory gating. PD subjects showed weaker sensory gating as evidenced by higher P50 ratios as compared to normal subjects (62.5% vs. 45.4%, p=0.03) and higher S2 (test) amplitude (3.5 microV vs. 2.1 microV, p=0.01). Schizophrenic subjects when compared to healthy controls showed higher P50 ratios as compared to normal subjects (79.2% vs. 45.4%, p<0.01) and higher S2 amplitude (3.3 microV vs. 2.1 microV, p=0.01), but were not statistically different from PD subjects (p>0.1). The present study corroborates recent findings of sensory gating dysfunction in PD. Further studies are still necessary to better understand the pathophysiology of this neurophysiological dysfunction and its nature as a trait or a state marker.

References

Mar 1, 1989·The American Journal of Psychiatry·M F BreslowD G Hope
May 1, 1988·The American Journal of Psychiatry·M A LeeO G Cameron
Jul 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L E AdlerJ M Giffith
Jan 1, 1996·Neuropsychobiology·D LevyA Elizur
Aug 1, 1996·Biological Psychiatry·H T NagamotoR Freedman
May 15, 1996·Biological Psychiatry·C R ClarkM Battersby
Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·A IwanamiK Kamijima
Jun 5, 1998·Schizophrenia Bulletin·L E AdlerR Freedman
Mar 14, 2002·Depression and Anxiety·S LudewigF X Vollenweider
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduardo S GhisolfiDiogo R Lara
Apr 5, 2003·Neuroscience Letters·Gilles van Luijtelaar
Jun 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen AlseneHarriet de Wit
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jijun WangChikara Ogura
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven P HamiltonJames A Knowles
Feb 14, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Eduardo S GhisolfiDiogo R Lara
Nov 10, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eduardo S GhisolfiDiogo R Lara

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Citations

Aug 20, 2009·Journal of Abnormal Child Psychology·Yael HenkinYair Bar-Haim
Aug 11, 2011·PloS One·Mitsuru KikuchiYoshio Minabe
Nov 10, 2009·Cognitive, Affective & Behavioral Neuroscience·Carly A YadonDeana B Davalos
Jan 19, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Taichi KurayamaEiji Shimizu
Dec 29, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Makoto NanbuEiji Shimizu
Jan 12, 2008·Psychiatry Research·Julie V PattersonWilliam E Bunney
Sep 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tasuku HashimotoMasaomi Iyo
May 12, 2010·Psychophysiology·Marie PrévostJ Bruno Debruille
Nov 4, 2008·Biological Psychiatry·Taichi KurayamaEiji Shimizu
Jan 28, 2015·Developmental Cognitive Neuroscience·Yael Henkin, Yair Bar-Haim
Jan 1, 2009·Journal of Psychophysiology·Marijn LijffijtAlan C Swann
May 7, 2015·Schizophrenia Bulletin·Randal G Ross, Robert Freedman
Nov 17, 2012·Neuropharmacology·Dilshani W N DissanayakeCharles A Marsden
Mar 13, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E V OrekhovaM Elam
Jan 18, 2015·Brain and Cognition·Sharon K HunterRandal G Ross
Mar 7, 2013·Comprehensive Psychiatry·Behice Han AlmisOzgur Aytas
May 26, 2017·PloS One·Nobuyuki TakeuchiMakoto Nishihara
May 19, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Zinaida I StorozhevaAnna V Kirenskaya
Jan 10, 2020·Clinical EEG and Neuroscience·Lars ThomaJens Plag
Dec 1, 2013·Trends in psychiatry and psychotherapy·Marcele Regine de CarvalhoPedro Ribeiro
Apr 6, 2021·Neurophysiologie clinique = Clinical neurophysiology·Özge YükselayHüseyin Güleç
Apr 5, 2019·Neuropsychobiology·Johannes RentzschJens Plag

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