p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche

The Journal of Biological Chemistry
Shun-Ichi KurataI Katoh

Abstract

p51/p63, a member of the tumor suppressor p53 gene family, is crucial for skin development. We describe here identification of ITGA3 encoding integrin alpha(3) as a target of its trans-activating function, proposing that p51/p63 allows epidermal stem cells to express laminin receptor alpha(3)beta(1) for anchorage to the basement membrane. When activated by genotoxic stress or overexpressed ectopically in non-adherent cells, p51/p63 transduced a phenotype to attach to extracellular matrices, which was accompanied by expression of ITGA3. Motifs matching the p53-binding consensus sequence were located in a scattered form in intron 1 of human ITGA3, and served as p51/p63-responsive elements in reporter assays. In addition to the trans-activating ability of the TA isoform, we detected a positive effect of the DeltaN isoform on ITGA3. The high level alpha(3) production in human keratinocyte stem cells diminished upon elimination of p51/p63 by small interfering RNA or by Ca(2+)-induced differentiation. Furthermore, a chromatin immunoprecipitation experiment indicated a physical interaction of p51/p63 with intron 1 of ITGA3. This study provides a molecular basis for the standing hypothesis that p51/p63 is essential for epidermal-mesenc...Continue Reading

References

Apr 1, 1992·Nature Genetics·W S el-DeiryB Vogelstein
Jun 1, 1983·The Journal of Cell Biology·J R Stanley, S H Yuspa
Feb 1, 1982·Journal of Cellular Physiology·M C TsaoR G Ham
Jan 13, 1995·Cell·P H JonesF M Watt
Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·B B TysnesR Bjerkvig
May 5, 1997·The Journal of Cell Biology·C M DiPersioR O Hynes
Jun 15, 1997·Experimental Cell Research·E A O'TooleD T Woodley
Jun 17, 1998·The EMBO Journal·K G McLure, P W Lee
Jun 1, 1999·Journal of Biochemistry·T TsujiT Irimura
Feb 26, 2000·Science·F M Watt, B L Hogan
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·K YamaguchiJ Jen
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·K HibiD Sidransky
Jan 4, 2001·Gynecologic Oncology·B J QuadeC P Crum
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·G PellegriniM De Luca
Mar 30, 2001·The Journal of Biological Chemistry·E C Thornborrow, J J Manfredi
May 18, 2001·Biochemical and Biophysical Research Communications·M OsadaY Ikawa
Sep 8, 2001·The Journal of Biological Chemistry·H NishiA C Johnson
Oct 20, 2001·The Journal of Biological Chemistry·Yasushi SasakiTakashi Tokino
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Hiroki HashidaMasayuki Miyake
Jan 31, 2002·Trends in Genetics : TIG·Annie YangFrank McKeon
Apr 20, 2002·Clinical & Experimental Metastasis·Tsutomu TsujiTatsuro Irimura
May 23, 2002·Developmental Cell·Hyunsook Lee, David Kimelman
Jun 19, 2002·Journal of Medical Genetics·H G BrunnerH Van Bokhoven
Sep 17, 2002·European Journal of Biochemistry·Takumi KatoTsutomu Tsuji
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Masaki NagataRitsuo Takagi

❮ Previous
Next ❯

Citations

Jun 14, 2005·Cell and Tissue Research·Tatsuya WatanabeYoji Ikawa
May 5, 2012·Cell Death and Differentiation·P GandelliniN Zaffaroni
May 23, 2006·Nature Cell Biology·Danielle K CarrollLeif W Ellisen
Dec 21, 2006·Cell Research·Feng LiYibin Kang
Oct 31, 2012·Human Molecular Genetics·Giustina FeroneCaterina Missero
Jul 1, 2005·Molecular and Cellular Biology·Motonobu OsadaDavid Sidransky
Oct 31, 2007·Izvestiia Akademii nauk. Seriia biologicheskaia·E A VoroteliakV V Terskikh
Dec 30, 2014·Current Eye Research·Masahiro YamaguchiSatoru Yamagami
Feb 19, 2016·Cell Cycle·Iyoko KatohShun-Ichi Kurata
Jan 13, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Karin RzepkaJohannes Wohlrab
Nov 22, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xiaoyan SunZhiyong Sheng
May 7, 2010·The Journal of Investigative Dermatology·Maranke I Koster
Jul 30, 2015·Science Signaling·Gerry MelinoFrancesca Bernassola
Mar 24, 2015·Biochimica Et Biophysica Acta·Evelyn N KouwenhovenHuiqing Zhou
Jan 13, 2006·Experimental Cell Research·Christopher E Barbieri, Jennifer A Pietenpol
Dec 6, 2005·Developmental Biology·Maranke I KosterDennis R Roop
Jan 29, 2011·The Journal of Allergy and Clinical Immunology·Chun Wei LiDe Yun Wang
Mar 31, 2005·Cell·Rebecca A IhrieLaura D Attardi
Feb 8, 2008·The Journal of Investigative Dermatology·Dario AntoniniCaterina Missero
Oct 13, 2006·The EMBO Journal·M Alessandra ViganòRoberto Mantovani
Jul 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Coert MargadantArnoud Sonnenberg
Aug 21, 2007·The Journal of Biological Chemistry·Paola ZigrinoCornelia Mauch
Nov 13, 2014·Experimental Dermatology·Maria Rosaria MolloCaterina Missero
Jun 5, 2019·International Journal of Molecular Sciences·Veronica GattiAngelo Peschiaroli
Oct 26, 2014·Journal of Cell Science·Takashi NakamuraYoshihiko Yamada
May 9, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L E Finlan, T R Hupp
Oct 7, 2008·Mechanisms of Development·Nadia DanilovaShuo Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.