PMID: 9432033Jan 31, 1998Paper

p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis

British Journal of Haematology
D LensD Catovsky

Abstract

To determine the role of the p53 gene in chronic lymphocytic leukaemia (CLL) and its possible involvement in the pathogenesis of a progressive form of CLL characterized by > 10%, prolymphocytes (CLL/PL), we selected 32 cases, 17 with typical morphology and 15 CLL/PL. The extent of inactivation of p53 was examined by assessing loss of heterozygosity (LOH) at 17p13.3, by sequencing the highly conserved region (exons 5-9) of the p53 gene and by analysing p53 protein expression. LOH was detected in 8/28 (29%) cases, p53 mutations in 5/32 (16%) cases and p53 expression in 5/27 (19%) cases. Overall 11 cases (30%) had p53 abnormalities of which eight cases had CLL/PL. There was a significant association between CLL/PL and p53 abnormalities (P=0.05); 75% of cases with LOH, 80% of p53 mutations and 80% of cases positive for p53 protein had CLL/PL. Thus, p53 inactivation is the first gene abnormality identified so far to be involved in the development of CLL/PL. All the cases with typical CLL and p53 abnormalities had only one allele affected whereas 4/6 CLL/PL had both alleles inactivated. This difference in the extent of p53 inactivation suggests that accumulation of p53 abnormalities may be associated with progression of CLL to CLL/PL...Continue Reading

Citations

Dec 30, 2004·Cytometry. Part B, Clinical Cytometry·Charles GoolsbyRonald B Gartenhaus
Apr 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Llorenç Coll-Mulet, Joan Gil
Nov 27, 1999·Leukemia Research·K VallianatouD Catovsky
Nov 7, 2000·Cancer Genetics and Cytogenetics·B EspinetL Florensa
Feb 14, 2002·British Journal of Haematology·Patrice ChevallierRichard Garand
Nov 11, 1999·British Journal of Haematology·A R PettittS D Griffiths
Oct 16, 1999·British Journal of Haematology·A R PettittJ C Cawley
Feb 13, 2001·British Journal of Haematology·T Hamblin
Jan 23, 1999·Current Opinion in Hematology·P M LydyardP Y Youinou
Oct 21, 2000·Molecular Pathology : MP·T J Bromidge, D J Howe
Apr 8, 1999·Leukemia & Lymphoma·A CrielC De Wolf-Peeters
Jul 7, 2009·Hematology/oncology Clinics of North America·Eric D Hsi
Dec 22, 2009·American Journal of Clinical Pathology·Hong ChangConnie X Y Qi
Jan 15, 2014·Human Mutation·Jitka MalcikovaSarka Pospisilova
Jan 10, 2014·International Journal of Laboratory Hematology·S MarionneauxE M Keohane
Apr 30, 2005·Cancer Genetics and Cytogenetics·Florence Nguyen-KhacHélène Merle-Béral
Feb 19, 1999·Lancet·A Reis
Apr 18, 2006·Seminars in Oncology·Biju KrishnanClaire Dearden
Sep 13, 2001·Clinical and Laboratory Haematology·C Fegan
Nov 7, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter HillmenJiri Mayer
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul MoretonPeter Hillmen
Oct 29, 2002·Leukemia & Lymphoma·T StankovicA M R Taylor
Aug 7, 2001·Reviews in Clinical and Experimental Hematology·E Matutes, A Polliack
Oct 13, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Cuc H DoBryone J Kuss
Aug 9, 2001·Reviews in Clinical and Experimental Hematology·F Caligaris-Cappio
Apr 14, 2000·Leukemia·E A KönigJ Demeter

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