p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production.

PloS One
Dana AustinKylene Kehn-Hall

Abstract

Rift Valley fever virus (RVFV) is an emerging viral zoonosis that is responsible for devastating outbreaks among livestock and is capable of causing potentially fatal disease in humans. Studies have shown that upon infection, certain viruses have the capability of utilizing particular cellular signaling pathways to propagate viral infection. Activation of p53 is important for the DNA damage signaling cascade, initiation of apoptosis, cell cycle arrest and transcriptional regulation of multiple genes. The current study focuses on the role of p53 signaling in RVFV infection and viral replication. These results show an up-regulation of p53 phosphorylation at several serine sites after RVFV MP-12 infection that is highly dependent on the viral protein NSs. qRT-PCR data showed a transcriptional up-regulation of several p53 targeted genes involved in cell cycle and apoptosis regulation following RVFV infection. Cell viability assays demonstrate that loss of p53 results in less RVFV induced cell death. Furthermore, decreased viral titers in p53 null cells indicate that RVFV utilizes p53 to enhance viral production. Collectively, these experiments indicate that the p53 signaling pathway is utilized during RVFV infection to induce cell ...Continue Reading

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Citations

Aug 29, 2014·Trends in Molecular Medicine·Oscar M Rollano PeñalozaMarek J Łos
Dec 3, 2014·Antiviral Research·Cathaleen MadsenKylene Kehn-Hall
Oct 9, 2013·Viruses·Saleh EifanAnne-Lie Blomström
Jan 24, 2016·Antiviral Research·Alan BaerKylene Kehn-Hall
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Normand CyrJames G Omichinski
Mar 22, 2013·The Journal of General Virology·Sabarish V IndranTetsuro Ikegami
Nov 1, 2017·Scientific Reports·Chelsea PinkhamKylene Kehn-Hall
Dec 14, 2018·The Journal of Veterinary Medical Science·Emel Aksoy, Ahmet Kursat Azkur
Jan 20, 2016·Expert Reviews in Molecular Medicine·Mahmoud IranpourSaeid Ghavami
Aug 5, 2017·Frontiers in Cellular and Infection Microbiology·Yue TengYigang Tong
Nov 15, 2018·Virus Genes·Natasha N GaudreaultJuergen A Richt
Mar 7, 2021·Viruses·Shanna S LeventhalDavid W Hawman
Jun 3, 2021·Viruses·Bibha DahalKylene Kehn-Hall

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Methods Mentioned

BETA
Assay
Infection
ubiquitination
confocal microscopy

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