p53 and HER-2/neu overexpression in ovarian borderline tumors

Gynecologic Oncology
G H EltabbakhR R Tubbs

Abstract

To study p53 and HER-2/neu expression in borderline ovarian tumors (BLOT) by assessing their frequency, coexpression, and relationship to histologic type, FIGO stage, tumor recurrence, and survival. Forty-two patients with confirmed BLOT (25 serous, 13 mucinous, and 4 seromucinous) were followed for 1.5 to 14 years (mean, 6.3). Thirty (71%) patients had FIGO stage I and 12 (29%) had FIGO stage III disease. Paraffin-embedded sections from the 42 BLOT, 5 normal ovaries, and 10 benign ovarian cystadenomas were stained using monoclonal antibodies against human p53 (DAKO-p53, DAKO, Denmark) and HER-2/neu (C-erB-2, Triton, Parkway, CA). Positive staining was semiquantitated depending on the number of positively stained tumor cells. p53 and HER-2/neu overexpressions were correlated to each other, to histologic subtype, stage, tumor recurrence, and survival. None of the patients had tumor recurrence. The 5- and 10-year disease-free survival was 100%. None of the normal ovaries or ovarian cystadenomas demonstrated overexpression of p53 or HER-2/neu. Ten (24%) BLOT demonstrated overexpression of p53 and 9 (21%) demonstrated overexpression of HER-2/neu. HER-2/neu overexpression was significantly greater in stage III than in stage I tumors...Continue Reading

References

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Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C. W. BurgerP. Kenemans
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S KusamuraL A L A Andrade
Feb 23, 2008·Biochimica Et Biophysica Acta·Jacqueline M LafkyNita J Maihle
Nov 5, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·David M Gershenson
Aug 17, 2005·American Journal of Clinical Pathology·Geza Acs
Feb 18, 2006·Cancer Treatment Reviews·Alberto Serrano-OlveraJaime De la Garza-Salazar
Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Federico PrefumoEzio Fulcheri
Mar 6, 2003·Human Mutation·Monique Schuijer, Els M J J Berns

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