Abstract
Twenty intramucosal tumors of "carcinoma-in-adenoma' and 43 adenomas (39 pyloric gland type, 4 intestinal type) of the gall-bladder were studied to establish more precise histological criteria of carcinoma or adenoma in cases of "carcinoma in pyloric gland type adenoma', to compare carcinoma in adenoma with pure, that is, without adenomatous components, carcinoma, and to confirm the benign nature of spindle cell foci in the adenomas. Ki-67 and p53 immunostaining and nuclear morphometry were used. Eight pure intramucosal cancers were used as controls. The formalin-fixed, paraffin-embedded sections were stained with p53 and Ki-67 antibodies. Spindle cell foci were observed only in the adenoma area of the pyloric gland type, with a frequency of 23% in 39 adenomas, and of 45% in 20 tumors of carcinoma-in-adenoma. Ki-67 staining was negative in 129 of 130 spindle cell foci examined, regardless of their size, and positive in only one focus (550 microns in size, Ki-67 index 0.2%). All of the spindle cell foci were negative for p53 stain. The Ki-67 positive index was 36.6 +/- 5.6% in the 8 pure carcinomas, and 12.5 +/- 1.9% in the cancer areas of 16 tumors with carcinoma-in-adenoma, while it was 7.9 +/- 1.7% in the adenoma areas of 16 ...Continue Reading
References
Nov 1, 1992·Human Pathology·H SasanoH Nagura
Sep 1, 1992·The Journal of Pathology·J GerdesG Cattoretti
Dec 1, 1992·The Journal of Pathology·G CattorettiJ Gerdes
Nov 1, 1991·The Journal of Pathology·R A WalkerJ M Varley
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N R RodriguesD P Lane
Jan 1, 1991·Acta Pathologica Japonica·K NishiharaM Enjoji
Jun 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiK L Kalra
Dec 1, 1991·Human Pathology·J Albores-SaavedraF Vuitch
Mar 24, 1990·Lancet·R IggoA L Harris
Apr 1, 1989·Acta Pathologica Japonica·H KijimaN Ishihara
Sep 1, 1989·Digestive Diseases and Sciences·W RemmeleU Schink
Apr 11, 1986·Cell·R A Saavedra, J A Huberman
Feb 1, 1988·Acta Pathologica Japonica·M YamamotoE Tahara
Feb 1, 1986·Diseases of the Colon and Rectum·S F CramerM F Graney
Jan 1, 1986·The American Journal of Surgical Pathology·J Albores-SaavedraD E Henson
Jul 1, 1967·The Annals of Thoracic Surgery·R R WatsonW Weisel
Nov 15, 1982·Cancer·S KozukaK Hachisuka
Jan 1, 1995·Pathology International·Y OohashiK Hatakeyama
Dec 1, 1993·Gastroenterology·M YounesJ Lechago
Jan 1, 1993·American Journal of Clinical Pathology·S YokoyamaA Moriuchi
Citations
Mar 30, 2010·Der Pathologe·R Kushima, M Vieth
Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Ryoji KushimaManfred Stolte
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ryoji KushimaTakanori Hattori
Jun 19, 2001·Cancer Letters·Y T KimC Y Kim
Jan 24, 2002·Cancer Letters·Ai-Min HuiMasatoshi Makuuchi
Sep 13, 2003·Cancer Letters·Masaharu KodaYoshikazu Murawaki
Mar 7, 2009·Biomedical Research·Ken-Ichi OkadaHiroyasu Makuuchi
Oct 1, 2010·Clinical Journal of Gastroenterology·Masahiro ShinodaYuko Kitagawa
May 1, 2008·Expert Opinion on Medical Diagnostics·Priya RupeshShukla Vijay Kumar
Apr 14, 2006·Neoplasia : an International Journal for Oncology Research·Matthias HofmannStefan Kippenberger
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Luis A Hidalgo GrauJavier Suñol Sala
Jul 6, 2018·The American Journal of Surgical Pathology·Cong HeTakashi Yao
Mar 30, 2006·The Kaohsiung Journal of Medical Sciences·Shen-Nien WangKing-Teh Lee
Oct 10, 2008·Virchows Archiv : an International Journal of Pathology·Yoji WaniMasayoshi Fujisawa
Sep 10, 2010·Virchows Archiv : an International Journal of Pathology·Michael ViethTakanori Hattori
Feb 7, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T TashiroS Yada
Apr 17, 2012·Pancreas·Yoko TatenoNobuyoshi Hiraoka
Jan 22, 2019·Advances in Medicine·Farid Saei Hamedani, Monica Garcia-Buitrago
Dec 10, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Farid Saei Hamedani, Monica Garcia-Buitrago
Apr 26, 2003·Virchows Archiv : an International Journal of Pathology·M ViethM Stolte
Jan 21, 2021·Microorganisms·Simone BertzMichael Vieth
Aug 19, 2007·Current Problems in Surgery·Sean P ClearySteven Gallinger