p53 and p21 expression in precancerous lesions and carcinomas of the uterine cervix: overexpression of p53 predicts poor disease outcome

Gynecologic Oncology
L W HuangT T Lee

Abstract

Abnormal expression of the p53 and p21(waf1/cip1) tumor suppressor genes has been observed in a variety of human tumors, but little is known about its expression during cervical tumorigenesis. To identify the potential implications of both genes in the development of cervical carcinoma and explore the clinical importance of changes in gene expression, we assessed the levels of both proteins in precancerous lesions and carcinomas of the cervix. In our study, 10 low-grade squamous intraepithelial lesions (LSIL), 35 high-grade squamous intraepithelial lesions (HSIL), 12 microinvasive carcinomas, and 103 invasive carcinomas were evaluated. The expression of p53 and p21 was studied by immunohistochemistry using monoclonal antibodies specific for these proteins. p21 was expressed in all samples of normal epithelium, LSIL, and HSIL, and the mean values of expression were 50.3, 42.5, and 44.5%, respectively. Conversely, the expression of p21 was significantly reduced in microinvasive (30.7%) and invasive carcinomas (9.9%). p53 nuclear staining was not detected in normal epithelium samples or LSILs, while 4 (11.4%) of 35 HSILs, 1 (8.3%) of 12 microinvasive carcinomas, and 38 (36.9%) of 103 invasive carcinomas were positive for p53. Comp...Continue Reading

References

Jul 5, 1991·Science·M HollsteinC C Harris
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jan 19, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A K LieR Holm
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz

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Citations

Aug 7, 2009·Pathology Oncology Research : POR·Lee-Wen HuangHeng-Ju Chen
Sep 30, 2010·Archives of Gynecology and Obstetrics·Nurcan Uluskan ÜnverErtugrul Colak
Feb 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Chang Ohk SungJe Ho Lee
Nov 26, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ruoyu ZhouWenru Tang
Aug 19, 2007·International Journal of Radiation Oncology, Biology, Physics·Ghee Young KwonWon Park
Jul 6, 2010·The Journal of Obstetrics and Gynaecology Research·Jitti HanprasertpongSathana Boonyapipat
Jan 7, 2014·Biochimica Et Biophysica Acta·Antonio Carlos de FreitasMaria da Conceição Gomes Leitão
Mar 4, 2003·Nature Reviews. Cancer·Peter BaldwinNicholas Coleman
Mar 14, 2007·International Journal of Cancer. Journal International Du Cancer·Astrid BaalbergenTheo J M Helmerhorst
Feb 24, 2005·Clinical Obstetrics and Gynecology·Luis Alfonso Padilla-Paz
Nov 13, 2004·Nihon rinsho. Japanese journal of clinical medicine·Masaki Inoue
Nov 1, 2005·Yonsei Medical Journal·Young Tae Kim, Min Zhao
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Dec 24, 2003·The Cancer Journal·Steven G Silverberg, Olga B Ioffe

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