PMID: 8603071Mar 18, 1996Paper

p53 and translational control

Biochimica Et Biophysica Acta
M E Ewen, S J Miller

Abstract

The tumor suppressor p53 plays a role in mediating a G1 arrest (for example, in response to DNA damage), in the cellular commitment to apoptosis and in suppression of transformation. The mechanism of action of p53 in each of these biological outcomes is likely to be overlapping. Current data indicate that p53 functions as a sequence specific transcriptional activator. p53 can also repress transcription from certain promoters. One way in which p53 mediates a G1 arrest after DNA damage appears to be clear. Cells exposed to ionizing radiation show elevated levels of p53 protein. The increase in p53 levels is thought to be responsible for the increase in the cyclin-dependent kinase (cdk) inhibitor p21 mediated through the p53 binding sites in the p21 promoter. With regard to the ability of p53 to suppress transformation, there is data suggesting that p53 functions other than, or in addition to, its transcriptional activation function may be necessary. Similar data exist for p53-dependent apoptosis. Recently a role for p53 at another level of gene regulation, namely, translational regulation has been proposed. p53 associates with various components of the translation machinery and has been implicated in the translational regulation ...Continue Reading

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Citations

Dec 5, 1998·The International Journal of Biochemistry & Cell Biology·I E SchefflerS Prieto
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·R JagusG N Barber
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·D B ZambleS J Lippard
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J JuE Chu
Oct 5, 2002·Nucleic Acids Research·Laura A Cassiday, L James Maher
Aug 4, 2010·Cold Spring Harbor Perspectives in Biology·Rachel Beckerman, Carol Prives
Aug 15, 2015·BioMed Research International·Marie-Jo HalabyDa-Qing Yang
Apr 24, 2016·Histochemistry and Cell Biology·Ambrogio P LonderoLaura Mariuzzi
Dec 7, 2005·The Journal of Pathology·Peter A Hall, W Glenn McCluggage
Jul 27, 2000·Molecular and Cellular Biology·S S MillardA Koff
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M GaleM G Katze
Jul 19, 2003·European Journal of Biochemistry·Constantina ConstantinouMichael J Clemens

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