PMID: 11317693Apr 25, 2001Paper

p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue

International Journal of Colorectal Disease
R BrollU Windhövel

Abstract

We evaluated p53 autoantibodies (p53-Ab) as a preoperative tumor marker and as a prognosis marker. We also investigated whether p53-Ab production is dependent on p53 protein overexpression in tumor tissue or on tumor volume. Serum samples of patients with a colorectal cancer (n = 130) and of healthy controls (n = 44) were examined for p53-Ab using an ELISA kit. P53 protein expression in tumor tissue was demonstrated immunohistochemically and quantified by ELISA. Tumor volume was calculated and patients' survival computed using the Kaplan-Meier method. p53-Ab were detected in the serum from 15% of patients; all controls were negative. There was a significant correlation between p53-Ab production and positive immunostaining or p53 protein concentration in tumor tissue. p53-Ab were detected at a higher percentage of patients with a tumor volume of 10 cm3 or greater than in those with a smaller tumor. No difference in patients' prognosis was found between the p53-Ab positive and negative groups. Because of their low sensitivity (15%) p53-Ab are not suitable as a preoperative tumor marker. However, their high specificity (100%) and their potential for early diagnosis of a tumor relapse makes them valuable for postoperative monitorin...Continue Reading

Citations

Mar 12, 2008·International Journal of Colorectal Disease·A SuppiahJ Greenman
Jun 8, 2013·Annals of Surgical Oncology·Romilda CardinFabio Farinati
Aug 8, 2013·World Journal of Gastroenterology : WJG·Aravind Suppiah, John Greenman
Jul 21, 2011·World Journal of Clinical Oncology·Oscar J CorderoF Javier Rodriguez-Berrocal
Jan 18, 2007·Expert Opinion on Therapeutic Targets·Hailing LuMary L Disis
Mar 22, 2007·Expert Opinion on Biological Therapy·Muhammad Wasif SaifKostas Syrigos
Jan 25, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chung-Wei FanErr-Cheng Chan
Jan 5, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vivian GoodellMary L Disis
Sep 20, 2019·Scandinavian Journal of Immunology·Shuxia LiuXiaohong Han
Oct 8, 2019·The International Journal of Biological Markers·Hejing WangJian Huang
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabrina HundtHermann Brenner
Sep 17, 2021·Journal of Cancer Research and Therapeutics·Roshan NiloofaL Suranjith Seneviratne

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