Abstract
Inactivation of tumor suppressor genes like p53 and p16 play a key role in tumor progression, with a high incidence of mutations existing for both genes in oral squamous cell carcinomas. Previous studies have demonstrated, (i) a correlation between the prevalence of p53 mutations and tobacco use [Brennan et al. (1995) New Engl. J. Med., 332, 712-717; Lazarus et al. (1996) Carcinogenesis, 17, 733-739], and (ii) a link between genotypes in specific xenobiotic metabolizing enzymes and oral cancer susceptibility [Park et al. (1997) Cancer Epid. Biomarkers Prev., 6, 791-797). In this paper, we present results of our examination of a series of 80 oral squamous cell carcinomas for p53 exons 5-9 and p16 exons 1-2 mutations, and the potential association of these mutations with specific genotyping patterns. p53 mutation prevalence in oral tumors was linked with increased patient tobacco use using several stratification criteria. There was a significantly higher prevalence of p53 mutations in OCSCCs from patients who smoked > 30 pack-years as compared to tumors from patients who smoked < or = 30 pack-years (OR = 2.8; CI = 1.1-7.2). No significant association was observed with patient alcohol consumption. There was a significant associati...Continue Reading
Citations
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·G Z QinP Lazarus
Aug 1, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xianlu ZhuoYinghui Tan
Apr 12, 2001·Cancer Genetics and Cytogenetics·D AktasE Tuncbilek
Apr 27, 2001·Toxicology Letters·M C MillerD A Bell
May 4, 2000·Oral Oncology·C ScullyH Tanzawa
Jul 19, 2000·Oral Oncology·C ScullyH Tanzawa
Mar 6, 2003·Oral Oncology·Milena Gasco, Tim Crook
Mar 23, 2002·Mutation Research·Bensu KarahalilEren Civelek
Jan 14, 2000·Mutation Research·H Autrup
Oct 3, 1999·Carcinogenesis·M SatoT Amagasa
Oct 3, 2002·Journal of the National Cancer Institute·Peter G Shields
Nov 29, 2007·Journal of the National Cancer Institute·Katie M ApplebaumKarl T Kelsey
Jan 6, 2000·Molecular Pathology : MP·A R CondeC Monteiro
Jun 27, 2007·BMC Cancer·Nadarajah VigneswaranWolfgang Zacharias
Jun 13, 2002·Environmental Health Perspectives·Carl-Elis BoströmRoger Westerholm
Jul 21, 2001·Lancet·X L Wang, M C Mahaney
Apr 23, 2013·Biochimica Et Biophysica Acta·Zakir Khan, Prakash S Bisen
May 25, 2002·Journal of Internal Medicine·H KuperP Boffetta
Feb 20, 2007·Oral Oncology·Yoshiki KurodaTakahiko Katoh
Mar 3, 2004·Environmental and Molecular Mutagenesis·Renata CanalleCatarina S Takahashi
Feb 18, 2009·Journal of Cutaneous Pathology·Mulazim H BukhariNaseer A Chaudhry
Sep 24, 2004·Cancer Genetics and Cytogenetics·Dilek AktasErgul Tuncbilek
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Yao-Ling LeeYi-Ching Wang
Jul 23, 2003·International Journal of Hygiene and Environmental Health·Ricarda ThierHermann M Bolt
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Megha RalliRajeev Sen
Mar 17, 2015·Oral Oncology·Paolo Boscolo-RizzoAnita De Rossi
May 12, 2011·Experimental Biology and Medicine·Zheng JiangXishan Wang
Nov 5, 2004·World Journal of Gastroenterology : WJG·Ahmed AbbasFrançois Sichel
Sep 20, 2017·Oncogene·G J OrtizG Lozano
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shadan AliPhilip A Philip
Jun 5, 2003·Pathologie-biologie·H RaybaudR A Monteil