p53, cancer and the immune response.

Journal of Cell Science
Julianna BlagihKaren H Vousden

Abstract

The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutation of p53 in cancers can affect the recruitment and activity of myeloid and T cells, allowing immune evasion and promoting cancer progression. p53 can also function in immune cells, resulting in various outcomes that can impede or support tumour development. Understanding the role of p53 in tumour and immune cells will help in the development of therapeutic approaches that can harness the differential p53 status of cancers compared with most normal tissue.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M DavidoffJ R Marks
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G P ZambettiA J Levine
Jan 1, 1971·Transplantation Reviews·F M Burnet
Oct 1, 1969·Annals of Internal Medicine·F P Li, J F Fraumeni
Jul 1, 1995·Nature Medicine·R LubinT Soussi
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L AgarwalG R Stark
Sep 1, 1995·British Journal of Cancer·J G HoubiersC J Melief
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y NoguchiL J Old
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J RothA J Levine
Apr 1, 1996·The Journal of Experimental Medicine·J I MayordomoA B DeLeo
Jan 6, 1997·International Journal of Cancer. Journal International Du Cancer·K AngelopoulouE P Diamandis
Jan 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Angelopoulou, E P Diamandis
Aug 29, 1997·The Journal of Experimental Medicine·M P VierboomC J Melief
Apr 29, 1998·Journal of Neurology·M WellerR Meyermann
Apr 17, 1999·Molecular and Cellular Biology·G A Webster, N D Perkins
Nov 24, 1999·The Journal of Experimental Medicine·J D HudsonD H Beach
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J HernándezL A Sherman
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E V FedoseyevaG Benichou
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T K HoffmannA B DeLeo
Dec 1, 2000·Nature·B VogelsteinA J Levine
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Sep 22, 2001·Science·M GirardiA C Hayday
Jan 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lorne J HofsethCurtis C Harris
Feb 11, 2003·Journal of Neuroimmunology·Yoshinobu OkudaClaude C A Bernard
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan EspenschiedJoshua D I Ellenhorn
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·G Fingerle-RowsonR Bucala
Aug 7, 2003·Experimental Hematology·Aru NarendranMelvin H Freedman
Nov 5, 2003·The Journal of Experimental Medicine·Santos MañesCarlos Martínez-A
Apr 7, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elena A KomarovaAndrei V Gudkov

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Citations

May 7, 2020·Cancers·Jian GaoAnja Ehrhardt
Jun 14, 2020·Genes·Therese WilhelmValeria Naim
Sep 26, 2020·Frontiers in Oncology·Vitaly ChasovEmil Bulatov
Sep 25, 2020·Journal of Experimental & Clinical Cancer Research : CR·Andrea SacconiGiovanni Blandino
Aug 23, 2020·Biomedicines·Shoib Sarwar SiddiquiCijo George Vazhappilly
Jun 12, 2020·International Journal of Molecular Sciences·Navid SobhaniYong Li
Jul 30, 2020·Journal of Molecular Cell Biology·Cen ZhangZhaohui Feng
Oct 11, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shivanshu AwasthiKosj Yamoah
Feb 5, 2021·Cancers·Chie Kudo-SaitoYamato Ogiwara
Jan 29, 2021·Frontiers in Oncology·Valeria CapaciGiannino Del Sal
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Eduardo Alvarado-OrtizAlejandro García-Carrancá
Apr 1, 2021·Seminars in Cancer Biology·Yanqing Liu, Wei Gu
Apr 17, 2021·Genes & Development·Steven PilleyKaren H Vousden
Apr 20, 2021·Oncoimmunology·Melania ScarpaIgnazio Castagliuolo
May 29, 2021·Cancer Gene Therapy·Evgeniya DenisovaSilke Redler
Jun 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Martino MaddalenaMoshe Oren
Jun 10, 2021·Oncogene·Thibaut BarnoudMaureen E Murphy
Jun 10, 2021·Therapeutic Advances in Medical Oncology·Anastasios GkountakosEmilio Bria
Jul 13, 2021·Frontiers in Immunology·Xin LuoPing Yi
Jul 10, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Júlio Santos-TerraCarmem Gottfried
Aug 7, 2021·Biomolecules·Thanh Binh NguyenChandra S Verma

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