p53 exon 5 mutations in two cases of leukemic mantle cell lymphoma

Cancer Genetics and Cytogenetics
D GandiniL del Senno

Abstract

Although p53 mutations have been described frequently in high-grade B-cell non-Hodgkin's lymphoma (NHL), they have only been reported occasionally in low-grade NHL. We therefore describe clincobiologic and molecular genetic findings in two patients with p53 mutations and leukemic mantle cell lymphoma featuring an unusually aggressive course. Circulating malignant cells showed irregularity of nuclear outline with frequent deep clefts in both cases. Immunologic studies of neoplastic cells from peripheral blood samples and from cells obtained from an involved lymph node showed a mantle B-cell phenotype (CD5+, CD19+, CD22+, CD23- or weakly+ and bright expression for surface immunoglobulins). Malignant cells were shown to be hyperdiploid by cytofluorimetric study of DNA content and the presence of the t(11;14)(q13q32) was documented in one case. An altered electrophoretic mobility of p53 exon 5 was seen in both cases, with a missense mutation at codon 158 present in one case and a CAG to TAG mutation resulting in a 167-stop codon present in the second case. The percent of reactive cells with the 1801 monoclonal antibody detecting an epitope of the p53 was 37% in one case and 1% in the second case, supporting the notion that immunolo...Continue Reading

References

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Citations

Dec 9, 1998·Cancer Genetics and Cytogenetics·C De AngeliL del Senno
Apr 11, 2002·Cell Research·Zhong Xia QiRui Yang Chen
Jan 17, 2002·Genes, Chromosomes & Cancer·Alicja M Gruszka-WestwoodDaniel Catovsky
Apr 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Armin PschererPeter Lichter
Apr 22, 1999·The Journal of Laryngology and Otology·N S AguileraS L Abbondanzo
May 30, 2019·American Journal of Clinical Pathology·Ji YuanZenggang Pan

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