PMID: 9450841Feb 5, 1998Paper

p53 expression and p53 gene mutation in oral cancer and dysplasia

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
H RowleyA S Jones

Abstract

The aim of the current study was to examine the possible association of the p53 tumor suppressor gene with the development of oral cancer. We examined biopsy material from patients with oral squamous cell carcinoma for p53 protein expression and p53 mutations. Eighteen samples were analyzed. These comprised oral squamous cell carcinoma biopsy samples and oral dysplastic biopsy material taken from nine patients. An immunohistochemical technique was used to determine p53 protein expression. A direct sequencing technique was used to detect mutations in the p53 gene itself. Overall seven of nine (77%) oral squamous cell carcinomas and seven of nine (77%) oral dysplastic lesions analyzed showed evidence of p53 protein over-expression. Mutations in exons 5 and 6 of the p53 gene were detected in five of nine (55%) oral squamous cell carcinomas and four of nine (44%) dysplastic lesions analyzed. Both p53 protein over-expression and p53 mutations were noted in dysplastic oral lesions. Over-expression of the p53 protein and p53 gene mutations were not always coexistent, however, suggesting that gene mutation may be only one of the mechanisms responsible for stabilization of the p53 protein.

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Citations

Jun 9, 2004·International Journal of Oral and Maxillofacial Surgery·Y-K ChenL-M Lin
May 2, 2014·Infectious Agents and Cancer·Cleberson Jean Dos Santos QueirozAmílcar Sabino Damazo
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Darren P Cox
Sep 13, 2003·Clinical Otolaryngology and Allied Sciences·Y K ChenL M Lin
Jun 23, 2015·The Journal of Pathology·Henry M WoodPamela Rabbitts
Apr 14, 2000·Clinics in Chest Medicine·T M Fitzpatrick, E A Blair
Mar 2, 2018·Genes·Alexandra Iulia IrimieIoana Berindan-Neagoe
Oct 17, 1998·The Journal of Laryngology and Otology·H Rowley
Jun 17, 2006·Molecular Cancer Research : MCR·Zhongqiu ZhangMing You

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