PMID: 8611406Apr 1, 1996Paper

P53 expression, DNA ploidy and S-phase cell fraction in operable locally advanced non-small-cell lung cancer

British Journal of Cancer
A CostaG Ravasi

Abstract

The identification of biomarkers to complement pathological stage for a more accurate prognosis and help clinicians decide on treatment is still an open problem for patients with lung cancer. Expression of P53 protein was detected by an immunohistochemical approach using the monoclonal antibody PAb1801 on paraffin-embedded sections of tumours obtained surgically from 102 stage II - IIIa patients with non-small-cell lung cancer (52 squamous cell carcinomas, 50 adenocarcinomas). [3H]Thymidine labelling index, an indicator of the S-phase cell fraction, was evaluated on histological sections of [3H]thymidine-labelled tumour samples. DNA ploidy was defined by flow cytometric analysis on frozen tumour tissue. The biomarkers, histology and pathological stage were analysed in relation to relapse-free survival in univariate and multivariate analyses. Stage and interaction between [3H]thymidine labelling index and histology provided significant prognostic information for the overall series. [3H]thymidine labelling index was an independent prognostic indicator of 3 year relapse-free survival in patients with adenocarcinoma. The results indicate the importance of cell proliferation to complement prognostic information provided by pathologi...Continue Reading

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Citations

May 29, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Yuka YamamotoMotoomi Ohkawa
Oct 3, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Yuka YamamotoMotoomi Ohkawa
Nov 6, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Reiko KameyamaYoshihiro Nishiyama
Aug 11, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroshi OtsukaHitoshi Shiozaki
Mar 1, 1997·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·J M Elias
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G SatoT Nukiwa
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A BonnerJ R Jett
Sep 24, 2009·Nuclear Medicine Communications·Yuka YamamotoYoshihiro Nishiyama
Jan 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Masatoshi HottaKazuhiko Yamada
Dec 23, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ryogo MinamimotoKazuo Kubota

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