p53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis

BMC Gastroenterology
Xiaohong LuShiyun Tan

Abstract

Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC. Publications were searched in the PubMed, Embase, EBSCO, Wangfang, and CNKI databases. The overall odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were summarized in this study. Final 19 papers were identified in this meta-analysis, including 1068 patients with UC and 130 normal tissue samples. Immunohistochemical p53 expression was significantly higher in UC without dysplasia and carcinoma (UC group) compared to normal tissue samples (OR = 3.14, P = 0.001), higher in UC with dysplasia than in UC group (OR = 10.76, P < 0.001), and higher in UC with colorectal cancer (CRC) than in UC with dysplasia (OR = 1.69, P = 0.035). Subgroup analysis of ethnicity (UC group vs. normal tissues) showed that p53 expression was correlated with UC in Asians, but not in Caucasians. When UC with dysplasia was compared to UC group, p53 expression was linked to UC with dysplasia among both Asians and Caucasians. When UC-CRC...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Dinh Nam TranEui-Bae Jeung
Jul 3, 2021·Cancers·Mehmet YalchinAilsa Hart
Jul 13, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Anuradha R Bhama, Muneera R Kapadia

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