PMID: 8600797Aug 1, 1995Paper

p53 expression is rare in cutaneous melanomas

The American Journal of Dermatopathology
M C Saenz-SantamaríaC R Shea

Abstract

Alterations in the tumor-suppressor gene p53 are common in many types of human malignancies, but the potential role of p53 in the pathogenesis of cutaneous melanoma is controversial. The gene product, p53 protein, is normally present in very small amounts in noncancerous tissues. Missense mutations lead to accumulation of mutant p53 in the cells, which makes it detectable immunohistochemically in many cancers. Formalin-fixed, paraffin-embedded sections of 14 primary invasive melanomas, 3 cutaneous melanoma metastases, and 10 predominantly intradermal melanocytic nevi were reacted with a panel of three anti-p53 monoclonal antibodies (mAbs) (PAb240, PAb1801, and DO7) and a mAb against Ki-67 (MIB-1), a marker of cellular proliferation. p53 was not detected in morphologically normal epidermal melanocytes or nevus cells. A single primary invasive melanoma, having a very high index of proliferation (Ki-67 expression in > 50% of cells), had diffuse nuclear labeling with all three anti-p53 mAbs used. Abnormalities of p53 expression occur rarely in cutaneous melanomas, but overexpression of p53 may occur in a subset of melanomas with a high index of proliferation.

Citations

Apr 1, 1996·Photochemistry and Photobiology·A P Albino, J W Fountain
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D Mehregan, D Mehregan
Jul 24, 2002·Journal of Cutaneous Pathology·Ning LiJag Bhawan
May 23, 2008·Journal of Cutaneous Pathology·Christina StefanakiAndreas Katsambas
Jun 22, 2000·Genes, Chromosomes & Cancer·I SaurojaS Pyrhönen
Apr 11, 2008·Journal of Cutaneous Pathology·Steven J OhsieScott W Binder
Dec 17, 2003·The British Journal of Dermatology·Y-C KimB-K Ahn
Apr 25, 2006·Surgical Oncology Clinics of North America·Alistair J CochranScott Binder

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