PMID: 9421356Jan 8, 1998Paper

p53 immunohistochemical staining and survival after adjuvant chemotherapy for breast cancer

International Journal of Cancer. Journal International Du Cancer
E A DublinD M Barnes

Abstract

We have investigated the relationship between immunohistochemically determined p53 status and outcome in 277 women with node-positive primary breast cancer who, following tumour excision and axillary clearance, were randomised to receive either 6 cycles of cyclophosphamide/methotrexate/S-fluorouracil (CMF) (n = 130) or no such post-operative treatment (n = 147). Follow-up data (median = 9 years) were available on all patients. A significant association was found between p53 status and survival. Patients with p53-positive tumours had a less favourable outcome than those with p53-negative disease. Women receiving adjuvant CMF chemotherapy had a significantly more favourable outcome compared to those who did not. The effect was seen both in women with p53-positive and p53-negative tumours; multivariate analysis showed relative risks for overall survival attributable to chemotherapy of 2.3 (95% CI 1.2-4.3) for women with p53-positive tumours and of 2.1 (95% CI 1.4-3.0) for those with p53-negative tumours. Thus, adjuvant chemotherapy with CMF is associated with a survival benefit in women with node-positive breast cancer irrespective of immunohistochemically determined p53 status.

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Citations

Mar 24, 2000·Pathology, Research and Practice·R González-CámporaA Gómez Pascual
Mar 7, 2001·The Journal of Molecular Diagnostics : JMD·P M DuddyR S Camplejohn
Aug 30, 2008·Human Pathology·Hajime KurodaShinji Itoyama
Mar 3, 2004·Pathology, Research and Practice·Václav VagundaHana Koukalová
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·D M Barnes
Dec 12, 2001·Breast Cancer Research : BCR·P N Munster, L Norton

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