p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner.

Molecular and Cellular Biology
I ChesnokovC W Schmid

Abstract

Wild-type p53 represses Alu template activity in vitro and in vivo. However, upstream activating sequence elements from both the 7SL RNA gene and an Alu source gene relieve p53-mediated repression. p53 also represses the template activity of the U6 RNA gene both in vitro and in vivo but has no effect on in vitro transcription of genes encoding 5S RNA, 7SL RNA, adenovirus VAI RNA, and tRNA. The N-terminal activation domain of p53, which binds TATA-binding protein (TBP), is sufficient for repressing Alu transcription in vitro, and mutation of positions 22 and 23 in this region impairs p53-mediated repression of an Alu template both in vitro and in vivo. p53's N-terminal domain binds TFIIIB, presumably through its known interaction with TBP, and mutation of positions 22 and 23 interferes with TFIIIB binding. These results extend p53's transcriptional role to RNA polymerase III-directed templates and identify an additional level of Alu transcriptional regulation.

References

Dec 1, 1992·Current Opinion in Genetics & Development·C Schmid, R Maraia
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E SetoT Shenk
May 8, 1992·Science·S E KernB Vogelstein
Jul 2, 1992·Nature·G FarmerC Prives
Nov 25, 1983·Nucleic Acids Research·M H Murphy, F E Baralle
Mar 25, 1994·Nucleic Acids Research·W M LiuC W Schmid
May 25, 1995·Nucleic Acids Research·W M ChuC W Schmid
Dec 1, 1993·Journal of Molecular Evolution·E P LeeflangC W Schmid

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Citations

Oct 17, 1998·DNA Sequence : the Journal of DNA Sequencing and Mapping·C G Larminie, R J White
Apr 22, 2014·FEBS Letters·Lior GolombMoshe Oren
Nov 5, 2008·Trends in Genetics : TIG·Robert J White
Jul 13, 2007·Biochemical and Biophysical Research Communications·Joby JacobLaura Schramm
Sep 3, 2009·Annals of the New York Academy of Sciences·Józefa Wesierska-Gadek, Vladimír Krystof
Jun 23, 2001·Journal of Molecular Biology·E P Geiduschek, G A Kassavetis
Dec 3, 2014·Biochimica Et Biophysica Acta·Simone J WoodsRoss D Hannan
Jan 7, 2011·Biology Direct·Feng CuiVictor B Zhurkin
Jan 6, 2007·Journal of Molecular Biology·Gemma MolaAna M Muñoz-Mármol
Aug 14, 2008·BMC Molecular Biology·Stephanie CabarcasLaura Schramm
Feb 19, 2004·Advances in Protein Chemistry·Robyn D Moir, Ian M Willis
Oct 27, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David Haig
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·A G WinterR J White
Aug 31, 2000·Journal of Molecular Biology·A M RoyP L Deininger
Jan 11, 2000·Journal of Cellular Biochemistry·S T Jacob, A K Ghosh
Nov 25, 2003·The EMBO Journal·David C ArthurJ N Mark Glover
Mar 16, 2004·The European Journal of Neuroscience·Juha-Pekka KalkkilaJari Honkaniemi
Apr 20, 2004·Oncogene·Robert J White
May 8, 2018·Cancers·Justina KasteriMoira Sauane
Dec 12, 1997·FEBS Letters·A J MighellP A Robinson
Nov 17, 2005·Journal of Cellular Biochemistry·Gang Liu, Xinbin Chen
Dec 16, 2006·Genes, Chromosomes & Cancer·Christy R Hagan, Charles M Rudin
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Robert J White
Oct 17, 2006·Apoptosis : an International Journal on Programmed Cell Death·Sugata MannaChinmay Kr Panda
Nov 7, 2008·Nature Reviews. Cancer·Lynne Marshall, Robert J White
Oct 5, 2010·Cell Cycle·Hélène Dumay-OdelotMartin Teichmann
Jan 6, 2012·The Journal of Biological Chemistry·Tharakeswari SelvakumarR William Henry
Feb 19, 1999·Oncogene·A Budde, I Grummt
Apr 27, 2000·The Journal of Biological Chemistry·Y Ueda, G Chaudhuri
Jun 6, 1997·The Journal of Biological Chemistry·W M ChuC W Schmid
Oct 1, 1998·Nucleic Acids Research·C W Schmid
Oct 9, 2002·The Journal of Biological Chemistry·Zoë A Felton-Edkins, Robert J White
Jan 20, 2004·Molecular and Cellular Biology·Koji NakadeBohdan Wasylyk
Jul 5, 2001·Molecular and Cellular Biology·K PlutaM Boguta
Jul 27, 2000·Molecular and Cellular Biology·W Zhai, L Comai

❮ Previous
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