p53 molecular approach to diagnosis and treatment of esophageal squamous cell carcinoma

Annals of Gastroenterological Surgery
Hideaki Shimada

Abstract

We reviewed our research concerning p53 molecules in esophageal squamous cell carcinoma by focusing on the p53 molecular diagnosis and treatment of esophageal squamous cell carcinoma. First, we developed diagnostic tools to analyze serum p53 autoantibodies to detect esophageal squamous cell carcinoma. Positive rate was around 25% to 30% in all patients and around 20% even in stage I patients. Presence of serum p53 antibodies was significantly associated with overexpression of p53 protein in tumor cells. Seropositive patients were more likely than seronegative patients to be resistant to chemotherapy. Monitoring of the titer of serum p53 autoantibodies was useful in predicting patients at high risk of recurrence and/or treatment response. Second, using Ad5CMV-p53 for 10 patients with advanced esophageal squamous cell carcinoma, we carried out a phase I/II study of adenoviral-mediated p53 gene therapy. Although no complete response was observed, local tumor was stabilized in nine patients. No serious adverse events related to Ad5CMV-p53 were observed in these patients. One patient survived for over 5 years after the start of p53 gene therapy. Intratumoral injection of Ad5CMV-p53 is therefore safe, feasible, and biologically activ...Continue Reading

References

Aug 26, 1998·The American Journal of Gastroenterology·H ShimadaK Isono
Apr 24, 1999·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·K NakajimaT Ochiai
Feb 24, 2010·Cancer Science·Hiroshi KawahiraHideaki Shimada
May 7, 2011·World Journal of Gastroenterology : WJG·Yong-Song GuanZi La
Jan 20, 2017·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Hiroshi TazawaToshiyoshi Fujiwara
Jan 18, 2018·Human Gene Therapy·Wei-Wei ZhangDominic Man-Kit Lam
Jun 13, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Kazuo KoyanagiYuji Tachimori
Jun 13, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Yasuo HamamotoTakahiro Higashi

❮ Previous
Next ❯

Citations

Jun 24, 2020·International Journal of Cancer. Journal International Du Cancer·Rei OkadaHideaki Shimada
Mar 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liu-Xiang WangXin-Qiang Zheng
Aug 5, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Mitsuro KandaYasuhiro Kodera
Jun 4, 2020·Annals of Gastroenterological Surgery·Isamu HoshinoHideaki Shimada
Nov 15, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yi-Wei XuYu-Hui Peng
Feb 23, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Hideaki Shimada
Oct 19, 2020·BMC Cancer·Isamu HoshinoHideaki Shimada
Nov 26, 2020·Annals of Surgical Oncology·Hideaki Shimada
Apr 22, 2021·Scientific Reports·Yusuke OkudaHiromi Kataoka
Jun 14, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qingzhu ZhengYi Huang
Oct 12, 2021·International Journal of Clinical Oncology·Tatsuki NanamiHideaki Shimada

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsies
biopsy

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Frontiers in Bioscience : a Journal and Virtual Library
Hideaki Shimada, Takenori Ochiai
Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
Jan D MaassJ A Werner
Esophagus : Official Journal of the Japan Esophageal Society
Takashi SuzukiHideaki Shimada
© 2022 Meta ULC. All rights reserved