PMID: 9193221Jun 1, 1997Paper

p53 mutation as a prognostic marker in advanced laryngeal carcinoma. Department of Veterans Affairs Laryngeal Cancer Cooperative Study Group

Archives of Otolaryngology--head & Neck Surgery
C R BradfordG T Wolf

Abstract

To determine the relationship of p53 mutations in advanced laryngeal carcinomas to p53 immunohistochemistry, organ preservation, and patient survival. Paraffin-embedded tumor specimens were obtained from patients enrolled in the Department of Veterans Affairs Laryngeal Cancer Cooperative Study, a multi-institutional randomized clinical trial comparing induction chemotherapy (cisplatin and fluorouracil) plus radiation therapy surgery plus postoperative radiation therapy. Tumor specimens were analyzed for p53 mutations in exons 5 through 8 by using single-strand conformational polymorphism (SSCP) analysis followed by DNA sequencing of all variants. Five-year follow-up data were available for all patients studied. Forty-four patients enrolled in the Department of Veterans Affairs Laryngeal Cancer Cooperative Study from whom paraffin-embedded tumor specimens were readily available. p53 immunostaining did not correlate with p53 SSCP and DNA sequencing results. More than half (62% [16/26]) of the tumors that overexpressed p53 immunohistochemically did not have a detectable p53 gene mutation. Similarly, 39% (7/18) of tumors that did not overexpress p53 did have a p53 gene mutation. p53 mutations were present in 39% of tumors tested. M...Continue Reading

Citations

Apr 23, 2008·Archives of Otolaryngology--head & Neck Surgery·Bhavna KumarCarol R Bradford
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bhavna KumarThomas E Carey
Mar 25, 1999·The Laryngoscope·J S ChomchaiG H Yoo
Mar 24, 2005·Cancer Metastasis Reviews·Max PartridgeXiaohong Huang
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Mar 6, 2007·Critical Reviews in Oncology/hematology·David J Stewart
Sep 24, 1999·Hematology/oncology Clinics of North America·C R Bradford
Jun 28, 2016·The Laryngoscope·Adam ScheelCarol Bradford
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bhuvanesh Singh, David G Pfister
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Jan 6, 2017·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Deuk-Won JoPil-Young Yun
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Mar 5, 2020·Laryngoscope Investigative Otolaryngology·Carol R BradfordAlessandra Rinaldo
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert MandicJochen A Werner

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