p53 mutation, deprivation and poor prognosis in primary breast cancer.

British Journal of Cancer
L BakerA M Thompson

Abstract

The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53 mutation might contribute to the impaired outcome observed in patients from deprived communities. p53 mutation status was determined using the Roche Amplichip research test in 246 women with primary breast cancer attending a single cancer centre and related to deprivation, pathology, overall, and disease-free survival. p53 mutation, identified in 64/246 (26%) of cancers, was most common in 10 out of 17 (58.8%) of the lowest (10th) deprivation decile. Those patients with p53 mutation in the 10th decile had a significantly worse disease-free survival of only 20% at 5 years (Kaplan-Meier logrank chi(2)=6.050, P=0.014) and worse overall survival of 24% at 5 years (Kaplan-Meier logrank chi(2)=6.791, P=0.009) than women of deciles 1-9 with p53 mutation (c.f. 56% and 72%, respectively) or patients in the 10th decile with wild-type p53 (no disease relapse or deaths). p53 mutation in breast cancer is associated with socio-economic deprivation and may provide a molecular basis, with therapeutic implications, for the poorer outcome in women from deprived communities.

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Citations

Apr 21, 2012·Pharmacogenomics·Colin McCowan, Alastair M Thompson
Dec 5, 2015·Expert Review of Molecular Diagnostics·Akihiro NishiShuji Ogino
Sep 14, 2015·Breast Cancer Research and Treatment·Heather M Ochs-BalcomPeter G Shields
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Oct 19, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji-Yeon KimYeon Hee Park
Feb 16, 2013·British Journal of Cancer·J H S DayalA M Thompson
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Dec 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Barbara KantorovaSarka Pospisilova

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